Skip to main content
Log in

Catastrophic Antiphospholipid Syndrome Triggered by Sepsis

  • Clinical Pathology Conference
  • Published:
HSS Journal

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

References

  1. Asherson RA, Cervera R, de Groot PG et al (2003) Catastrophic Antiphospholipid Syndrome Registry Project Group. Catastrosphic antiphospholipid syndrome: international consensus statement on classification criteria and treatment guidelines. Lupus 12:530–534

    Article  PubMed  CAS  Google Scholar 

  2. Rand JH (2002) Molecular pathogenesis of antiphospholipid syndrome. Circ Res 90:29–37

    Article  PubMed  CAS  Google Scholar 

  3. Cervera R, Asherson RA (2006) Catastrophic antiphospholipid syndrome. J Pathophy Haem Thrombosis 181–186

  4. Erkan D, Yazici Y, Peterson MG et al (2002) A cross-sectional study of clinical thrombotic risk factors and preventive treatments in antiphospholipid syndrome. Rheumatology 41:924–929

    Article  PubMed  CAS  Google Scholar 

  5. Vero SK, Asherson RA, Erkan D (2006) Catastrophic antiphospholipid syndrome. J Intensive Care Med 21:144–159

    Article  Google Scholar 

  6. Alpert D, Mandl LA, Erkan D et al (2008) Anti-heparin platelet factor 4 antibodies in systemic lupus erythaematosus are associated with IgM antiphospholipid antibodies and the antiphospholipid syndrome. Ann Rheum Dis 67:395–401

    Article  PubMed  CAS  Google Scholar 

  7. Galli M, Finazzi G, Barbui T (1996) Thrombocytopenia in the antiphospholipid syndrome. Brit J Haem 93:1–5

    Article  CAS  Google Scholar 

  8. Erkan D, Cervera R, Asherson RA (2003) Catastrophic antiphospholipid syndrome: where do we stand? Arthritis Rheum 48(12):3320–3327

    Article  PubMed  Google Scholar 

  9. Cervera R, Font J, Gomez-Puerta JA et al (2005) Validation of the preliminary criteria for the classification of catastrophic antiphospholipid syndrome. Ann Rheum Dis 64:1205–1209

    Article  PubMed  CAS  Google Scholar 

  10. Amital H, Levy Y, Davidson C et al (2001) Catastrophic antiphospholipid syndrome: remission following leg amputation in 2 cases. Semin Arthritis Rheum 31(2):127–132

    Article  PubMed  CAS  Google Scholar 

  11. Erkan D, Asherson RA, Cervera R et al (2004) Plasma exchange or intravenous immunoglobulins in catastrophic antiphospholipid syndrome. In: 7th International Lupus Congress Abstract Book. New York: 15; 265–268

  12. Sherer Y, Levy Y, Shoenfeld Y (2000) Intravenous immunoglobulin therapy of antiphospholipid syndrome. Rheumatology 39:421–426

    Article  PubMed  CAS  Google Scholar 

  13. Bayry J, Lacroix-Desmazes S, Kazatchkine MD et al (2004) Intravenous immunoglobulin for infectious disease: back to the pre-antibiotic and passive prophylaxis era? Trends Pharmacol Sci 25:306–310

    Article  PubMed  CAS  Google Scholar 

  14. Uthman I, Shamseddine A, Taher A (2005) The role of therapeutic plasma exchange in the catastrophic antiphospholipid syndrome. Transfus Apher Sci 33:11–17

    Article  PubMed  Google Scholar 

  15. Ehrsemann S, Arkfeld D, Shinada S et al (2004) A novel therapeutic approach for catastrophic antiphospholipid syndrome when conventional therapy with anticoagulants and steroids were unsuccessful [abstract]. Ann Rheum Dis 64(suppl):FR10278

    Google Scholar 

  16. Erre GL, Pardini S, Faedda R et al (2008) Effect of riuximab on clinical and laboratory features of antiphospholipid syndrome: a case report and a review of literature. Lupus 17:50–55

    Article  PubMed  CAS  Google Scholar 

  17. Miyakis S, Lockshin MD, Atsumi T et al (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4(2):295–306

    Article  PubMed  CAS  Google Scholar 

  18. Pierangeli S, Chen P, Gonzalez E (2006) Antiphospholipid antibodies and the antiphospholipid syndrome: an update on treatment and pathogenic mechanisms. Curr Opin Hematol 13:366–375

    Article  PubMed  CAS  Google Scholar 

  19. Wolberg AS, Roubey RA (2004) Mechanisms of autoantibody-induced monocyte tissue factor expression. Thromb Res 114:391–396

    Article  PubMed  CAS  Google Scholar 

  20. Godeau B, Piette J, Fromont P et al (1997) Specific antiplatelet glycoprotein autoantibodies are associated with the thrombocytopenia of primary antiphospholipid syndrome. Brit J of Haem 98:873–879

    Article  CAS  Google Scholar 

  21. Kitchens CS (1998) Thrombotic storm: when thrombosis begets thrombosis. Am J Med 104:381–385

    Article  PubMed  CAS  Google Scholar 

  22. Espinosa G, Cervera R, Asherson R (2007) Catastrophic antiphospholipid syndrome and sepsis: a common link? JRheum 34:923

    CAS  Google Scholar 

  23. Erkan D (2006) Therapeutic and prognostic considerations in catastrophic antiphospholipid syndrome. Autoimmun Rev 6:98–103

    Article  PubMed  CAS  Google Scholar 

  24. Burcoglu-O’Ral A, Erkan D, Asherson RA (2002) Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator. J Rheumatol 29:2006–2011

    PubMed  Google Scholar 

  25. Registry of the “European forum on antiphospholipid antibodies” for patients with the “catastrophic” antiphospholipid syndrome. http://www.med.ub.es/MIMMUN/FORUM/CAPS.HTM (accessed on August 8th, 2008)

Download references

Acknowledgments

The authors would like to thank Dr. Maria DeSancho and Dr. Daluiski for their presentations and discussions during the clinical pathology conference.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Susan Kim M.D..

Additional information

A Clinical Pathology Conference held by the Department of Rheumatology at Hospital for Special Surgery

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kim, S., Moskowitz, N.K., DiCarlo, E.F. et al. Catastrophic Antiphospholipid Syndrome Triggered by Sepsis. HSS Jrnl 5, 67–72 (2009). https://doi.org/10.1007/s11420-008-9103-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11420-008-9103-6

Keywords

Navigation