HSS Journal

, Volume 5, Issue 1, pp 49–50

SH3BP2 is a Critical Regulator of Macrophage and Osteoclast Response to M-CSF and RANKL Stimulation


DOI: 10.1007/s11420-008-9091-6

Cite this article as:
McMahon, M.S. & Ueki, Y. HSS Jrnl (2009) 5: 49. doi:10.1007/s11420-008-9091-6


The protein Src homology 3 domain-binding protein 2 (SH3BP2) is a regulator of tumor necrosis factor (TNF)-alpha generation in macrophages and of osteoclast differentiation. SH3BP2 regulates bone marrow monocyte responses to macrophage and osteoclast differentiation signals downstream of the receptors for macrophage colony-stimulating factor and receptor activator of nuclear factor kappaB ligand. SH3BP2 is a potential target for the development of novel anti-TNF-alpha therapeutic interventions as well as a target for suppression of osteoclastogenesis.


SH3BP2 macrophage osteoclast M-CSF RANKL 

Copyright information

© Hospital for Special Surgery 2008

Authors and Affiliations

  1. 1.Department of Orthopedic SurgeryBeth Israel Deaconess Medical CenterBostonUSA
  2. 2.Department of Developmental BiologyHarvard School of Dental MedicineBostonUSA

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