Abstract
Purpose
Since the early 2010s, synthetic opioids have been on the rise in the illicit drug markets of North America and Europe, often as adulterants or substitutes for heroin. Ocfentanil, an early-onset fentanyl analogue, has been implicated in several fatalities, predominantly in Europe. W-18 is more prevalent in Canada and the United States. We present the findings for an unknown brown powder, advertised and purchased as heroin, which was sent to our laboratory for analysis in the framework of the Belgian Early Warning System on Drugs.
Methods
The sample was screened using liquid chromatograph coupled to a diode array detector and gas chromatograph coupled to a single quadrupole mass spectrometer. The findings were confirmed by liquid chromatography—triple quadrupole mass spectrometry.
Results
No heroin, 6-monoacetylmorphine or morphine was detected. Our analysis detected two new psychoactive substances: the synthetic opioid ocfentanil (1.6% m/m), and W-18 (0.3% m/m). The ocfentanil concentration was similar to those found in previous reports. No reference concentrations have been published for W-18. The presence of these two new psychoactive substances together in the same powder is unprecedented and prompted a warning by the Belgian Early Warning System on Drugs.
Conclusion
The unknown powder tested positive for ocfentanil and W-18. To the authors’ best knowledge this is the first case of the combined detection of these two new psychoactive substances in the same powder. We additionally demonstrate the advantage of building an in-house reference library beyond retention time.
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Abbreviations
- CSL:
-
Cayman Spectral Library
- dMRM:
-
Dynamic multiple reaction monitoring
- DAD:
-
Diode array detector
- GC:
-
Gas chromatography
- LC:
-
Liquid chromatography
- MS:
-
Mass spectrometry
- QQQ:
-
Triple quadrupole mass spectrometer
- RT:
-
Retention time
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Acknowledgements
The authors would like to thank Tessa Windelinckx (Free Clinic vzw, Schijnpoortweg 14, 2060 Antwerp, Belgium) for providing the sample.
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Alexander van Nuijs received a postdoctoral scholarship from the Research Foundation Flanders (FWO, Grant no. 1285216N).
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Degreef, M., Blanckaert, P., Berry, E.M. et al. Determination of ocfentanil and W-18 in a suspicious heroin-like powder in Belgium. Forensic Toxicol 37, 474–479 (2019). https://doi.org/10.1007/s11419-019-00480-3
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DOI: https://doi.org/10.1007/s11419-019-00480-3