Identification of new synthetic cannabinoid analogue APINAC (adamantan-1-yl 1-pentyl-1H-indazole-3-carboxylate) with other synthetic cannabinoid MDMB(N)-Bz-F in illegal products
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Two synthetic cannabinoid analogues were detected using high-performance liquid chromatography (HPLC)–diode array detector, and gas chromatography–time-of-flight-mass spectrometry during the inspection of illegal products in an airmail package. The analogues were separated by semi-preparative HPLC, and their structures were determined by performing liquid chromatography–high-resolution-mass spectrometry, infrared analysis, and nuclear magnetic resonance spectroscopy. Compound 1 was MDMB(N)-Bz-F, which has been reported previously. Compound 2 was elucidated as adamantan-1-yl 1-pentyl-1H-indazole-3-carboxylate (APINAC), in which the amide group of APINACA was replaced with an ester group. Because there has been no chemical or pharmacological data about this compound until now, this is the first report of its detection in illegal products.
KeywordsMethyl 2-[1-(4-fluorobenzyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate 1-(4-Fluorobenzyl)-N-(1-methoxycarbonyl-2,2-dimethylpropyl)-1H-indazole-3-carboxamide [MDMB(N)-Bz-F] Adamantan-1-yl 1-pentyl-1H-indazole-3-carboxylate (APINAC) Synthetic cannabinoids Illegal product APINACA analogues
This research was supported by Research Grants (15181MFDS521 and 15182MFDS523) from the Ministry of Food and Drug Safety (MFDS) in Korea. We thank the Central Laboratory of Kangwon National University for providing us with technical assistance on the spectroscopic experiments.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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