Identification and characterization of a new designer drug thiothinone in seized products
- 464 Downloads
In the last 10 years, the abuse of designer drugs has proliferated due to the ease of purchase on the Internet. Our research laboratory collaborates with the Financial Police (GdF) analyzing drugs of abuse on behalf of the Court (Procura della Repubblica––Tribunale di Busto Arsizio). Nine products sold on the Internet and suspected to contain illegal substances were brought to our laboratory after a seizure at the Malpensa Airport in Northern Italy. After first routine analyses carried out by thin-layer chromatography (TLC) and gas chromatography/flame ionization detection (GC/FID), we were able to exclude all “classical” drugs and common new psychoactive substances (NPSs). This prompted us to deeply analyze the unknown product to identify it by different analytical techniques. The structure of the unknown compound was elucidated by gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), accurate mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. This characterization allowed us to identify the unknown substance as a new designer drug thiothinone, [2-(methylamino)-1-(2-thienyl)-1-propanone]. The X-ray powder diffraction (XRPD) pattern and the analytical data presented herein can provide valid support to forensic chemists who may encounter this “legal high” in caseworks. To our knowledge, this is the first scientific disclosure of thiothinone from dubious products.
KeywordsThiothinone Thienyl analogue of cathinone NPS GC/MS LC/MS NMR
Compliance with ethical standards
Conflict of interest
There are no financial or other relations that could lead to a conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- 6.Lopez-Avila V, Gao W, Urdahl R (2012) Mass spectral fragmentation of cathinones by high-resolution TOFMS using a soft ionization source. J Pharm Sci Innov 1:44–53Google Scholar
- 7.de Castro A, Lendoiro E, Fernandez-Vega H, Lopez-Rivadulla M, Cruz A, Steinmeyer S (2014) Liquid chromatography tandem mass spectrometry determination of selected synthetic cathinones and two piperazines in oral fluid. Cross reactivity study with an on-site immunoassay device. J Chromatogr A 1374:93–101PubMedCrossRefGoogle Scholar
- 9.Das R, Ali E, Abd Hamid SB (2014) Current applications of X-ray powder diffraction—a review. Rev Adv Mater Sci 38:95–109Google Scholar
- 13.Casale JF, Hays PA (2011) Methiopropamine: an analytical profile. Microgram J 8:53–57Google Scholar
- 15.https://drugs-forum.com/forum/showthread.php?p=1359978#post1359978. Accessed Sep 2013
- 16.Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y (2013) Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicol 31:223–240CrossRefGoogle Scholar