Diphenidine and its metabolites in blood and urine analyzed by MALDI-Q-TOF mass spectrometry
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New psychoactive substances that are different from synthetic cannabinoids or cathinone derivatives have appeared very recently on illicit drug markets. In 2014, three reports were published on diphenidine distribution in Japan. The first study characterized diphenidine and 1-benzylpiperidine in a powdered product called “fragrance powder” , while the second determined diphenidine and 5-fluoro-AB-PINACA in a dubious herbal product . The third study dealt with a fatal case in which a victim smoked a herbal product containing diphenidine together with a herbal product containing AB-CHMINACA and 5-fluoro-AMB . The postmortem distributions of these substances determined by gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–tandem mass spectrometry (LC–MS-MS) indicated that the main cause of death was diphenidine poisoning . To date, the toxicity and metabolism of diphenidine have not been studied in any scientific context because it is a...
KeywordsPhenyl Ring Amitriptyline Piperidine Herbal Product Cathinone
This work was supported by a Grant-in-Aid for Scientific Research (Number 2560867) from the Ministry of Education, Science, Sports, and Culture of Japan.
Conflict of interest
There are no financial or other relations that could lead to a conflict interest.
Informed consent was obtained from all individuals included in the study, who supplied about 1 ml each of whole blood for use as blank matrix.
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