Forensic Toxicology

, Volume 33, Issue 1, pp 1–11 | Cite as

25B-NBOMe and its precursor 2C-B: modern trends and hidden dangers

  • Ioannis Papoutsis
  • Panagiota NikolaouEmail author
  • Maria Stefanidou
  • Chara Spiliopoulou
  • Sotiris Athanaselis
Review Article


Substituted phenethylamines are a class of designer drugs that hold a significant position in the drug abuse market. The most important substances within this class appear to be 4-bromo-2,5-dimethoxyphenethylamine (2C-B) and its novel derivative 2-(4-bromo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamine (25B-NBOMe). Intoxications related to 2C-B use are still recorded worldwide, despite the fact that its use and trafficking are banned in many countries. 25B-NBOMe is a highly potent 2C-B derivative that has invaded recently in the “drug arena” and is considered legal to possess and supply in many countries. This manuscript reviews all available information regarding chemistry, availability, pharmacology, and toxicology of 2C-B and 25B-NBOMe. The intoxication and fatal cases reported, as well as the current legislation of these drugs, are also presented.


2C-B Nexus 25B-NBOMe New Nexus Substituted phenethylamines Toxicology and pharmacology 


Conflict of interest

There are no financial or other relations that could lead to a conflict of interest.


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Copyright information

© Japanese Association of Forensic Toxicology and Springer Japan 2014

Authors and Affiliations

  • Ioannis Papoutsis
    • 1
  • Panagiota Nikolaou
    • 1
    Email author
  • Maria Stefanidou
    • 1
  • Chara Spiliopoulou
    • 1
  • Sotiris Athanaselis
    • 1
  1. 1.Department of Forensic Medicine and Toxicology, Faculty of MedicineNational and Kapodistrian University of AthensAthensGreece

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