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Simultaneous determination of coinage metals, copper, silver, and gold in tissues using electrospray ionization tandem mass spectrometry

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Abstract

A rapid and sensitive mass spectrometric method was developed for the simultaneous determination of the coinage metals of copper (Cu), silver (Ag), and gold (Au). The metals in a wet-ashed tissue solution were complexed with diethyldithiocarbamate (DDC; C4H10NCS2) and were extracted with isoamyl alcohol. After acidification of the extract with oxalic acid, metals were quantified using their product ions, Cu(DDCH)+, Ag(DDCH)+, and Au(DDCH)+ that derived from the precursor ions Cu(DDC)  +2 , Ag(DDC)  +2 , and Au(DDC)  +2 , respectively, by electrospray ionization tandem mass spectrometry. The limits of detection were 0.6, 0.3, and 1 μg/l for Cu, Ag, and Au, and the quantification ranges were 2–100, 1–100, and 3–100 μg/l for Cu, Ag, and Au, respectively. Cu levels in spontaneously hypertensive osteogenic disorder rats at 6 weeks of age and 30 weeks of age were found to be 1.8 times and 5.1 times those of the normotensive osteogenic disorder rats, respectively, when using wet-ashed kidney solutions diluted 1000-fold.

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Acknowledgments

This work was supported by a Grant-in-Aid for Scientific Research (No. 22590631) from the Ministry of Education, Science, Sports, and Culture of Japan.

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Authors and Affiliations

  1. Department of Legal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan

    Kayoko Minakata, Itaru Yamagishi, Hideki Nozawa, Kunio Gonmori, Koutaro Hasegawa, Kanako Watanabe & Osamu Suzuki

  2. Research Equipment Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan

    Masako Suzuki

  3. Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8691, Japan

    Fumihiko Horio

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  1. Kayoko Minakata
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  2. Itaru Yamagishi
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  3. Hideki Nozawa
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  4. Kunio Gonmori
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  8. Kanako Watanabe
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  9. Osamu Suzuki
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Correspondence to Kayoko Minakata.

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Minakata, K., Yamagishi, I., Nozawa, H. et al. Simultaneous determination of coinage metals, copper, silver, and gold in tissues using electrospray ionization tandem mass spectrometry. Forensic Toxicol 30, 149–155 (2012). https://doi.org/10.1007/s11419-012-0134-9

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  • DOI: https://doi.org/10.1007/s11419-012-0134-9

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