Skip to main content
Log in

A fatal case of poisoning by lormetazepam

  • Case Report
  • Published:
Forensic Toxicology Aims and scope Submit manuscript

Abstract

Lormetazepam is a benzodiazepine widely used as a hypnotic for management of insomnia. It is considered to be a safe drug when not combined with alcohol or other psychoactive substances. Indeed, we could neither fi nd its toxic nor lethal concentrations in the literature. In the present article, we report a fatal case in which lormetazepam and its metabolite lorazepam were the only drugs found in body fl uids. The concentration measured in blood was more than 100 times higher than the therapeutic one. Therefore, we concluded that the death was due to the drug and that the measured levels could be regarded as lethal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Baselt RC (2004) Disposition of toxic drugs and chemicals in man, 7th edn. Biomedical, Foster City, pp 623–624

    Google Scholar 

  2. Repetto MR, Repetto M (1997) Habitual, toxic, and lethal concentrations of 103 drugs of abuse in humans. Clin Toxicol 35:1–9

    Article  CAS  Google Scholar 

  3. Winek CL, Wahba WW, Winek CLJr, Balzer TW (2001) Drugs and chemical blood-level data 2001. Forensic Sci Int 122:107–123

    Article  PubMed  CAS  Google Scholar 

  4. The International Association of Forensic Toxicologists (TIAFT) (2007) Reference blood level list of therapeutic and toxic substances. http://www.tiaft.org/tmembers/ttv/ttv_el.php. Accessed Sep 2008

  5. Dams R, Benijts THP, Lambert WE, Van Bocxlaer JF, Van Varenberg D, Van Peteghem C, De Leenheer AP (2001) A fatal case of serotonin syndrome after combined moclobemide-citalopram intoxication. J Anal Toxicol 25:147–151

    PubMed  CAS  Google Scholar 

  6. Uralets VP, Gillette PA, Latven RK (1988) Fruitful application of steroid methodology for drug of abuse testing: comprehensive benzodiazepine screening and confi rmation. In: Schanzer W (ed) Recent advances in doping analysis (5). Proceedings of the 15th Cologne workshop on dope analysis. Verlag Sport und Buch Strauss, Cologne, pp 317–328

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Carmelo Furnari.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Furnari, C., Ottaviano, V. & De Lellis, M. A fatal case of poisoning by lormetazepam. Forensic Toxicol 26, 85–86 (2008). https://doi.org/10.1007/s11419-008-0053-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11419-008-0053-y

Keywords

Navigation