Abstract
Menthae Herba is an herbal medicine whose name is written with the same kanji characters (薄荷) in both the Japanese Pharmacopoeia, 18th Edition (JP) and in the Pharmacopoeia of the People’s Republic of China (CP). However, the original plant are Mentha arvensis Linné var. piperascens Malinvaud in JP and Mentha haplocalyx Briq. in CP. To clarify the similarities and differences between Menthae Herba in Japan and that in China, morphological observations, essential oil component analysis, and DNA analysis were performed on marketed products of Menthae Herba in Japan and in China. The morphological observations based on the description of JP Menthae Herba showed that most of the samples matched the items listed in the description. Essential oil component analysis by gas chromatography–mass spectrometry showed that the amount of menthol varied among samples and that menthol was not always the principal compound in the oil. The original plant species was confirmed by DNA analysis of the rpl16 intron region in chloroplast DNA and all samples matched the sequence of M. canadensis. The results showed that Menthae Herba products distributed in both Japan and China contained M. canadensis, but they had different compositions of essential oil, with menthol-rich Menthae Herba being dominant in the Japanese market.
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References
The Ministry of Health, Labour and Welfare (2021) The Japanese Pharmacopoeia 18th edition. The Ministry of Health, Labour and Welfare, Tokyo, pp 20–27
Chinese Pharmacopoeia Commission (2020) Pharmacopoeia of the People’s Republic of China. China Medical Science Press, China, pp 394–395
Lawrence BM (2006) Mint: the genus Mentha. CRC Press, Boca Raton, pp 18–19
WFO (2023) Mentha canadensis L. Published on the Internet. http://www.worldfloraonline.org/taxon/wfo-0000240492. Accessed 29 Oct 2023
Masumoto N, Ito M (2023) Genetic identification of the original plant species for Mentha Herb listed in the Japanese Pharmacopoeia and analyses of their essential oil composition. J Nat Med 77(3):489–495
The Japan Liaison of Oriental Medicine (2024) What is ISO/TC249?. http://jlom.umin.jp/page2.html. Accessed 25 Mar 2024
Tucker AO, Chambers HL (2002) Mentha canadensis L. (Lamiaceae): a relict amphidiploid from the lower tertiary. Taxon 51(4):703–718
Kimura M (2015) For the popularization and promotion of herbs -history and current situation, necessary information, role of national herb summit-. Tokusanshubyo 21:68–72
Kawasaki M (2015) Historical changes in mint production areas and current situation in India, the main production area. Tokusanshubyo 21:73–77
Acknowledgements
The authors are very grateful to the Japan Kampo Medicines Manufacturers Association for providing the samples for this study.
Funding
This work was partially supported by AMED (Grant No. 23mk0101199j0003).
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H.N. designed and carried out the experiments and analyzed the data; M.I. designed and supervised the experiments.
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Negishi, H., Ito, M. Comparison of Menthae Herba written with the same kanji characters (薄荷) in Japan and China. J Nat Med (2024). https://doi.org/10.1007/s11418-024-01822-1
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DOI: https://doi.org/10.1007/s11418-024-01822-1