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Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus

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Abstract

Two new lindenane-type sesquiterpenoid dimers, chlotrichenes C and D (1 and 2) together with five known lindenane-type sesquiterpenoid dimers (3–7) were isolated from the roots of Chloranthus holostegius var. trichoneurus, a famous natural medicine named as “Sikuaiwa” for subduing swellings and relieving pain. The structures including absolute configuration were elucidated by their 1D and 2D NMR, HRESIMS, and ECD data. Compounds 1 and 2 were classical [4 + 2] lindenane-type sesquiterpenoid dimers that differed from known analogs in oxidation profile, side chain profile, and double bond position. The new isolates and compound 3 exhibited significant inhibitory activity on IL-1β production (IC50: 1–15 μM) in LPS-induced THP-1 cells and other compounds exhibited inhibitory activity on NO production in LPS-induced RAW 264.7 cells (IC50: 24–33 μM).

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Data will be made available on request.

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Acknowledgements

The work was supported by the National Natural Science Foundation of China (32070389), and the “Double First-Class” University project of China Pharmaceutical University (CPU2022QZ29).

Funding

The work was supported by the National Natural Science Foundation of China (32070389), and the “Double First-Class” University project of China Pharmaceutical University (CPU2022QZ29).

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Author notes

  1. Xiaoli Wang and Zhenyu Zan have contributed equally to this work.

Authors and Affiliations

  1. Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China

    Xiaoli Wang, Jun Chi, Danyang Zhang, Houli Jiang & Jun Luo

  2. School of Food Science and Pharmaceutical Engineering, Testing & Analysis Center, Nanjing Normal University, Xuelin Road No. 2, Nanjing, 210023, People’s Republic of China

    Zhenyu Zan, An Huang & Yi Li

Authors
  1. Xiaoli Wang
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Contributions

XW: Biological activities assessment; drafting and revising of the article. ZZ: Isolation and identification of the compounds; drafting of the article. JC: Isolation and identification of the compounds. AH, DZ, HJ: Refinement of the manuscript. YL, JL: Funding acquisition; Project administration; Writing—review & editing.

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Correspondence to Yi Li or Jun Luo.

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Wang, X., Zan, Z., Chi, J. et al. Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus. J Nat Med (2024). https://doi.org/10.1007/s11418-024-01817-y

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