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Alliaxylines A–E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss

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Abstract

A total of five new mexicanolides (1–5), namely alliaxylines A–E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI–MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC50 values of 34.95 ± 0.21 and 44.39 ± 1.03 µM.

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Acknowledgements

The authors would like to thank the facilities of Universitas Padjadjaran, Centre for Higher Education Funding (BPPT) Ministry of Education, Culture, Research and Technology, also the Indonesia Endowment Fund for Education (LPDP).

Funding

This work was partly supported by Academic Leadership Grant No 1959/UN6.3.1/PT.00/2023 awarded to Unang Supratman, by Centre for Higher Education Funding (BPPT) Ministry of Education, Culture, Research and Technology, and also by the Indonesia Endowment Fund for Education (LPDP).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia

    Sandra Amalia Riyadi, Al Arofatus Naini & Unang Supratman

  2. Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia

    Sandra Amalia Riyadi, Al Arofatus Naini, Tri Mayanti, Ronny Lesmana & Unang Supratman

  3. Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia

    Ronny Lesmana

  4. School of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800, Penang, Malaysia

    Mohamad Nurul Azmi

  5. Research Center for Chemistry, National Research and Innovation Agency (BRIN), Kawasan PUSPITEK Serpong Tangerang, Selatan, 15314, Indonesia

    Sofa Fajriah

  6. Department of Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand

    Siriporn Jungsuttiwong

Authors
  1. Sandra Amalia Riyadi
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  2. Al Arofatus Naini
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  3. Tri Mayanti
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  8. Unang Supratman
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Contributions

US, TM, RL, and SJ assisted in conducting the experiments, performed the spectral analysis, and wrote the manuscript. SAR, AAN, SF, and MNA designed and conducted all experiments, as well as wrote the manuscript. All authors have read and approved the final manuscript.

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Correspondence to Unang Supratman.

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Riyadi, S.A., Naini, A.A., Mayanti, T. et al. Alliaxylines A–E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss. J Nat Med (2024). https://doi.org/10.1007/s11418-024-01794-2

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