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New nitric oxide production inhibitors from Syzygium bullockii

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Abstract

Three undescribed triterpene glycosides syzybullosides A-C (1–3) along with fourteen known compounds were isolated from the leaves of Syzygium bullockii (Hance) Merr.& L.M. Perry, including six triterpene glycosides (1–6), four phenolics (7–9, 17), four megastigmanes (10–13), and three flavonoids (14–16). The structures of 1–17 were elucidated by extensive spectroscopic analysis, including IR, HR-ESI–MS, 1D and 2D NMR spectra. Compounds 1–10 and 12–17 inhibited nitric oxide (NO) production in lipopolysaccharide activated RAW264.7 cells with IC50 values ranging from 1.30 to 13.70 µM, lower than that of the positive control compound, L-NMMA (IC50 = 33.8 µM).

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Acknowledgements

This research was supported by the Vietnam Academy of Science and Technology (NCXS01.02/22-24).

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Authors and Affiliations

  1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

    Bui Huu Tai, Pham Hai Yen, Duong Thi Dung, Nguyen Huy Hoang, Nguyen Xuan Nhiem & Phan Van Kiem

  2. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

    Bui Huu Tai, Bui Hai Ninh & Phan Van Kiem

  3. Hai Phong University of Medicine and Pharmacy, 72A Nguyen Binh Khiem, Ngo Quyen, Hai Phong, Vietnam

    Bui Hai Ninh & Nguyen Van Tuyen

  4. Mien Trung Institute for Scientific Research, Vietnam National Museum of Nature, VAST, Huynh Thuc Khang, 321, Hue, Thua Thien Hue, Vietnam

    Le Tuan Anh

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  1. Bui Huu Tai
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Tai, B.H., Ninh, B.H., Yen, P.H. et al. New nitric oxide production inhibitors from Syzygium bullockii. J Nat Med 77, 964–971 (2023). https://doi.org/10.1007/s11418-023-01725-7

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  • DOI: https://doi.org/10.1007/s11418-023-01725-7

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