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Two new β-carboline alkaloids from the roots of Anemone altaica

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Abstract

Two new β-carboline alkaloids, anemonilins A and B (1–2), and two known β-carboline alkaloids, flazine (3) and 4-(9H-β-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots of Anemone altaica. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1D and 2DNMR, HRESIMS). Compounds 2 and 4 significantly attenuated the growth inhibition induced by lipopolysaccharide (LPS) in normal rat kidney tubule epithelioid (NRK52e) cells (p < 0.05 or p < 0.01). Furthermore, compound 2 significantly reduced the apoptosis (p < 0.05) and the caspase-3/9 expression of NRK52e cells induced by LPS.

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Data availability

The data that support the findings of this study are available from the corresponding authors upon reasonable request.

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Acknowledgements

This work was financially supported by the Key Projects for Science and Technology Development of Henan Province, China (No. 172102310537).

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Authors and Affiliations

  1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China

    Kun Du, Meng-Nan Zeng, Yan-Zhi Wang & Yu-Fei Liu

  2. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Construction By Henan Province & Education Ministry of People’s Republic of China, Zhengzhou, 450046, China

    Kun Du, Yan-Zhi Wang & Wei-Sheng Feng

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  1. Kun Du
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  2. Meng-Nan Zeng
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  3. Yan-Zhi Wang
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Correspondence to Yan-Zhi Wang.

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Du, K., Zeng, MN., Wang, YZ. et al. Two new β-carboline alkaloids from the roots of Anemone altaica. J Nat Med 77, 397–402 (2023). https://doi.org/10.1007/s11418-023-01679-w

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  • DOI: https://doi.org/10.1007/s11418-023-01679-w

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