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Dibenzocyclooctadiene lignans from Artemisia sieversiana and their anti-inflammatory activities

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Abstract

Abstract

Two previously undescribed dibenzocyclooctadiene lignans, named sieverlignans D–E (1–2), as well as eight known ones (3–10), were isolated from the aerial parts of Artemisia sieversiana. Their structures were elucidated from extensive spectroscopic analysis, including HRMS, NMR and electronic circular dichroism (ECD) experiments. This study is the first to report dibenzocyclooctadiene lignans in the genus Artemisia and this plant. All the compounds were evaluated for their anti-neuroinflammatory activities on the lipopolysaccharides (LPS)-induced nitric oxide production in BV-2 murine microglial cells. Compounds 1 and 6 exhibited the moderate activities with their IC50 values of 47.7 and 21.9 μM, compared to a positive control quercetin with the IC50 value of 16.0 μM.

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Acknowledgements

The authors express thanks to the analytical center of Peking University Health Science Center for measurements of MS and NMR. This work is financially supported by grants from the National Natural Science Foundation of China (Nos. 81903514 and 81473106) and the key research and Development Projects of Hunan Science Technology Department (No.2016NK2133).

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Authors and Affiliations

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China

    Xu-Dong Zhou, Xi-Kang Zheng, Ke-Wu Zeng & Peng-Fei Tu

  2. TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Innovative Materia Medica Research Institute, Human University of Chinese Medicine, Changsha, 410208, China

    Xu-Dong Zhou, Li-Min Gong & Wei Wang

  3. College of Life Science and Technology, Southwest Minzu University, Chengdu, 610041, Sichuan, China

    Chao-Xi Chen

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  1. Xu-Dong Zhou
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Correspondence to Wei Wang or Peng-Fei Tu.

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Zhou, XD., Chen, CX., Zheng, XK. et al. Dibenzocyclooctadiene lignans from Artemisia sieversiana and their anti-inflammatory activities. J Nat Med 75, 1014–1020 (2021). https://doi.org/10.1007/s11418-021-01532-y

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