Abstract
New copaene-type and nerolidol-type sesquiterpenoids, 7-hydroxymustakone (1) and 15-hydroxynerolidol (2), and a 15-norlabdane diterpenoid, kaempcandiol (3), together with four known compounds (4–7) were isolated from the chloroform extract of Kaempferia candida roots and rhizomes. The structures of the new compounds 1–3 were elucidated based on 1D and 2D NMR and HRESIMS spectroscopic analyses. The extract of the K. candida roots and rhizomes and all isolated compounds 1–7 possessed HIV-1 viral protein R (Vpr) inhibitory activities on the TREx-HeLa-Vpr cell line at a 5 μM concentration, without detectable cytotoxicity.
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Acknowledgements
This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI Grants, JP20H00490, JP20KK0173, JP19H04649).
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Prema, Kodama, T., Nyunt, H.H.W. et al. Anti-Vpr activities of sesqui- and diterpenoids from the roots and rhizomes of Kaempferia candida. J Nat Med 75, 489–498 (2021). https://doi.org/10.1007/s11418-020-01480-z
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DOI: https://doi.org/10.1007/s11418-020-01480-z