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Four new pyrrole alkaloids from the rhizomes of Amomum koenigii

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Abstract

Four new pyrrole alkaloids, named amokoens A–D (1–4), together with three known compounds (5–7) were isolated from the rhizomes of Amomum koenigii. Their structures and absolute configurations were established by spectroscopic data, including 1D and 2D NMR, and the optical rotation calculations. All the isolates were evaluated for their effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages. Compounds 1–7 inhibited NO production ranging from 27.1 to 82.4% at a concentration of 100 μM, and compounds 5 and 6 showed efficacious inhibitory activities with IC50 values of 42.2 and 69.3 µM, respectively.

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Acknowledgements

We gratefully acknowledge Dr. Yun Deng in School of Pharmacy, Chengdu University of TCM, for the help in OR calculations. This work was supported by the National Natural Science Foundation of China [No. 31600275], the Key Project Plans of Synergetic Innovation in Yangling Demonstration [No. 2018CXY-03], and the Doctoral Starting Fund of Xinxiang Medical University [No. XYBSKYZZ201813].

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Authors and Affiliations

  1. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, 712100, China

    Hong Yin & Jin-Ming Gao

  2. School of Pharmacy, Xinxiang Medical University, Xinxiang, 453000, China

    Chao Guo

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  1. Hong Yin
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  2. Chao Guo
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Correspondence to Jin-Ming Gao.

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Yin, H., Guo, C. & Gao, JM. Four new pyrrole alkaloids from the rhizomes of Amomum koenigii. J Nat Med 75, 173–177 (2021). https://doi.org/10.1007/s11418-020-01461-2

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