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Two new rearranged clerodane diterpenes from Thai Tinospora baenzigeri

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Abstract

A new rearranged clerodane-type diterpene (1), tinobaenzigeride, and a new rearranged clerodane glucoside (2) were isolated from the stems of Tinospora baenzigeri, along with four known compounds (3‒6). Their structures were elucidated by spectroscopic data analysis. In addition, the structure and configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 1 are a rare example of rearranged clerodanes, since it contains a fully oxygenated tetrahydrofuran moiety. The isolated compounds were evaluated for their cytotoxicity against Hep-G2 and MCF-7 cancer cells, none of them did show any significant activity at 25 μM.

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Acknowledgements

The authors gratefully acknowledge the financial support provided by the 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund). T.A. is grateful to the Ratchadapisek Sompoch Endowment Fund (CU-GR_62_53_23_19), Chulalongkorn University, for partial support of X-ray diffraction facility.

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Authors and Affiliations

  1. Graduate Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

    Sujitra Hanthanong

  2. Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

    Siwattra Choodej, Thammarat Aree & Khanitha Pudhom

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  1. Sujitra Hanthanong
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  2. Siwattra Choodej
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  3. Thammarat Aree
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  4. Khanitha Pudhom
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Correspondence to Khanitha Pudhom.

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Hanthanong, S., Choodej, S., Aree, T. et al. Two new rearranged clerodane diterpenes from Thai Tinospora baenzigeri. J Nat Med 75, 201–206 (2021). https://doi.org/10.1007/s11418-020-01450-5

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