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Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities

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Abstract

Three new steroidal saponins, aspiletreins A–C (1–3), together with 2H-chromen-2-one (4), and α-tocopherol (5), were isolated from whole Aspidistra letreae plants collected in Vietnam. Their structures were elucidated by a combination of spectroscopic analyses, including 1D- and 2D-NMR, IR, and HRESIMS, and by comparison with the reported data in the literature. Compounds 1–3 exhibited moderate cytotoxicities against the LU-1, HeLa, MDA-MB-231, HepG2, and MKN-7 human cancer cell lines, with IC50 values ranging from 7.69 ± 0.40 to 20.46 ± 3.11 µM.

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Acknowledgements

This work was financially supported by Hue University (ID No. DHH2019-04-101) and in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI Grants JP17H02203 and 19H04649). We are grateful to Mr. Luong Vu Dang (Institute of Chemistry, VAST, Hanoi, Vietnam) for recording the NMR spectra.

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Authors and Affiliations

  1. Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Vietnam

    Duc Viet Ho, Hung Quoc Vo, Khan Viet Nguyen & Hoai Thi Nguyen

  2. Faculty of Basic Science, Hue University of Agriculture and Forestry, Hue University, 102 Phung Hung, Hue, Vietnam

    Hanh Nhu Thi Hoang

  3. Faculty of Chemistry, Hue University of Education, Hue University, 34 Le Loi, Hue, Vietnam

    Ty Viet Pham

  4. Quang Tri Center of Science and Technology, Mientrung Inst. for Scientific Research, VAST, Dien Bien Phu, Dong Ha, Quang Tri, Vietnam

    Anh Tuan Le

  5. Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

    Kiem Van Phan

  6. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam

    Hien Minh Nguyen

  7. Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan

    Hiroyuki Morita

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  1. Duc Viet Ho
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Correspondence to Hiroyuki Morita or Hoai Thi Nguyen.

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Ho, D.V., Hoang, H.N.T., Vo, H.Q. et al. Three new steroidal saponins from Aspidistra letreae plants and their cytotoxic activities. J Nat Med 74, 591–598 (2020). https://doi.org/10.1007/s11418-020-01395-9

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  • DOI: https://doi.org/10.1007/s11418-020-01395-9

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