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Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats

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Abstract

In our previous study, we found that the methanolic extract of Sanoshashinto (三黄瀉心湯) (SHXXTM) exhibited significant vasorelaxant effects in vitro and antihypertensive effects in vivo, and baicalin and berberine were the main antihypertensive constituents in SHXXTM. We also speculated that the baicalin–berberine (BB) combination produced vasorelaxant effects by activating the NO/cGMP pathway, and the BKCa channel and the DAG/PKC/CPI-17 pathway were involved. In this study, we examined the vasorelaxant effects using helical strips of rat aorta pretreated with different activators or inhibitors. The results suggested that the KATP channel and the voltage-dependent Ca2+ channel (VDCC) were also involved in the vasorelaxant effects. Furthermore, we found that SHXXTM and the BB combination reduced left ventricular hypertrophy and altered gut microbiota. Together, the results indicated that Sanoshashinto might have comprehensive effects on ameliorating hypertension.

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Authors and Affiliations

  1. Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan

    Jianbo Wu, Souichi Nakashima, Seikou Nakamura & Hisashi Matsuda

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  1. Jianbo Wu
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  2. Souichi Nakashima
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  3. Seikou Nakamura
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  4. Hisashi Matsuda
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Correspondence to Hisashi Matsuda.

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Wu, J., Nakashima, S., Nakamura, S. et al. Effects of Sanoshashinto on left ventricular hypertrophy and gut microbiota in spontaneously hypertensive rats. J Nat Med 74, 482–486 (2020). https://doi.org/10.1007/s11418-020-01387-9

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  • DOI: https://doi.org/10.1007/s11418-020-01387-9

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