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Chemical constituents from the roots of Lindera aggregata and their biological activities

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Abstract

Three new benzylisoquinoline alkaloids, (1′S)-12′-hydroxyl-linderegatine (1), (1S)-5′-O-p-hydroxybenzoyl norreticuline (2), (1R, 1′R)-11,11′-biscoclaurine (3), along with 18 known compounds were isolated from the roots of Lindera aggregata (Sims) Kosterm. Their structures were determined on the basis of extensive spectroscopic analysis (IR, UV, HR-ESI–MS, 1D and 2D NMR). The absolute configurations of three new compounds were determined by comparing their experimental and calculated ECD for the first time. Compounds (4) and (9) showed cytotoxic activities against human colon carcinoma cell line (HCT-116), with IC50 values of 51.4 and 27.1 μM, respectively. Furthermore, compounds (10) and (11) showed inhibitory activities on nitric oxide production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells, with IC50 values of 37.8 and 38.7 μM, respectively.

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Author notes

  1. Jun-Jie Yang and Yi Chen contributed equally to this work

Authors and Affiliations

  1. The MOE Key Laboratory of Standardization of Chinese Medicines, SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China

    Jun-Jie Yang, Yi Chen, Mei-Li Guo & Gui-Xin Chou

  2. Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, 201203, China

    Jun-Jie Yang, Yi Chen, Mei-Li Guo & Gui-Xin Chou

Authors
  1. Jun-Jie Yang
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  2. Yi Chen
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  3. Mei-Li Guo
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  4. Gui-Xin Chou
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Correspondence to Gui-Xin Chou.

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Yang, JJ., Chen, Y., Guo, ML. et al. Chemical constituents from the roots of Lindera aggregata and their biological activities. J Nat Med 74, 441–447 (2020). https://doi.org/10.1007/s11418-019-01385-6

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