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New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella

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Abstract

Three new polyacetylenic alcohols, siphonellanols A–C (1–3), together with two known polyacetylenic alcohols (4–5), were isolated from the CHCl3-soluble fraction of the methanolic extract of the marine sponge Siphonochalina siphonella, collected in Egypt. The structures of 1–3 were determined by spectroscopic analyses of their 1D-, 2D-NMR, and MS spectra and by comparisons with reported data. The cytotoxicity assay revealed that 1–3 exhibited moderate cytotoxic activities against a human cervical cancer cell line (HeLa), a human breast cancer cell line (MCF-7), and a human lung cancer cell line (A549) with IC50 values ranging from 25.9 to 69.2 μM.

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Acknowledgements

This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan (JSPS KAKENHI Grants JP17H05435 and 19H04649) and the TWAS-COMSTECH Research Grant Award_17-056 RG/PHA/AF/AC_C, TWAS/UNESCO, 2018.

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Authors and Affiliations

  1. Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan

    Dae-Won Ki, Ahmed H. El-Desoky, Chin Piow Wong & Hiroyuki Morita

  2. Pharmaceutical Industries Research Division, Pharmacognosy Department, National Research Centre, 33 El Bohouth St. (Former El Tahrir St.), Dokki, P.O. 12622, Giza, Egypt

    Ahmed H. El-Desoky

  3. Red Sea Marine Parks, Egyptian Environmental Affairs Agency (EEAA), Hurghada, Egypt

    Mohamed Abdel-Ghani

  4. Chemistry of Natural and Microbial Products Department, National Research Centre, 33 El Bohouth Street (Former El Tahrir Street), Dokki, P.O. 12622, Giza, Egypt

    Ahmed A. El-Beih

  5. Faculty of Pharmaceutical Sciences, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan

    Mineyuki Mizuguchi

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  1. Dae-Won Ki
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  2. Ahmed H. El-Desoky
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  3. Chin Piow Wong
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  4. Mohamed Abdel-Ghani
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  5. Ahmed A. El-Beih
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  6. Mineyuki Mizuguchi
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  7. Hiroyuki Morita
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Correspondence to Ahmed H. El-Desoky or Hiroyuki Morita.

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Ki, DW., El-Desoky, A.H., Wong, C.P. et al. New cytotoxic polyacetylene alcohols from the Egyptian marine sponge Siphonochalina siphonella. J Nat Med 74, 409–414 (2020). https://doi.org/10.1007/s11418-019-01377-6

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  • DOI: https://doi.org/10.1007/s11418-019-01377-6

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