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Isolation and identification of two new compounds from the twigs and leaves of Cephalotaxus fortunei

  • Qingmei Feng
  • Bingxin Li
  • Yuan Feng
  • Xingyu Li
  • Xiaorui Ma
  • Haifeng Wang
  • Gang ChenEmail author
Note
  • 188 Downloads

Abstract

Two new compounds, namely 5-hydroxy-7-methoxy-6-methylchromone (1), and sesquiterpene X (6), together with 21 known compounds were isolated from the twigs and leaves of Cephalotaxus fortunei Hook. f. The structures of 1–23 were elucidated on the basis of spectroscopic analysis (1D/2D NMR, HR-ESI–MS and IR) and comparison with literature. The absolute configuration of compound 6 was determined by means of electronic circular dichroism calculation. The in vitro anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing lipopolysaccharide-induced nitric oxide production. Compounds 1 and 6 exhibited weak effects with percentage inhibitions of 24% and 35.60%, respectively. In addition, compounds 4, 9, and 14 have the potential to be developed as therapeutic agents for inflammatory diseases because of their significant anti-inflammatory activities and high content in C. fortunei.

Keywords

Cephalotaxus fortunei Hook. f. Anti-inflammatory activities Structure elucidation 

Notes

Acknowledgements

This work was supported by the young and middle-aged teachers’ career development support plan of Shenyang Pharmaceutical University (2017); Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology (LMDBKF201701).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.

Supplementary material

11418_2019_1308_MOESM1_ESM.docx (7.2 mb)
Supplementary material 1 (DOCX 7397 kb)

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Copyright information

© The Japanese Society of Pharmacognosy 2019

Authors and Affiliations

  • Qingmei Feng
    • 1
    • 2
  • Bingxin Li
    • 1
    • 2
  • Yuan Feng
    • 1
    • 2
  • Xingyu Li
    • 1
    • 2
  • Xiaorui Ma
    • 1
    • 2
  • Haifeng Wang
    • 1
    • 2
  • Gang Chen
    • 1
    • 2
    Email author
  1. 1.School of Traditional Chinese Materia MedicaShenyang Pharmaceutical UniversityShenyangChina
  2. 2.Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research and DevelopmentShenyangChina

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