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Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells

Journal of Natural Medicines volume 73, pages 597–601 (2019)Cite this article

Abstract

Chaga mushrooms, the sclerotium of Inonotus obliquus, have been used in Mongolia as a traditional hair shampoo to maintain healthy hair. Bioassay-guided fractionations of the extract of Chaga mushrooms using a proliferation assay on human follicle dermal papilla cells (HFDPCs) gave five lanostane-type triterpenes (1–5), whose structures were identified by spectroscopic evidence. Among these, lanosterol (1), inotodiol (3), lanost-8,24-diene-3β,21-diol (4), and trametenolic acid (5) demonstrated proproliferative effects on HFDPCs more potent than minoxidil, an anti-alopecia agent, used as the positive control. The lanostane-type triterpenes (1, 3, 4, and 5) appeared to be potential candidates of new agents possibly used for hair-care with a stimulative effect on hair growth.

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Acknowledgements

This study was partly supported by JSPS KAKENHI Grant numbers JP22406024 and JP26305003, and by SVENSON Co., Ltd., Tokyo, Japan.

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Affiliations

  1. Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan

    Kazumi Sagayama, Naonobu Tanaka & Yoshiki Kashiwada

  2. Graduate School of Technology, Industrial and Social Sciences, Tokushima University, Tokushima, 770-8513, Japan

    Naonobu Tanaka

  3. SVENSON Co., Ltd., Tokyo, 107-0052, Japan

    Takatoshi Fukumoto

Authors
  1. Kazumi Sagayama
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  2. Naonobu Tanaka
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  3. Takatoshi Fukumoto
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  4. Yoshiki Kashiwada
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Correspondence to Yoshiki Kashiwada.

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Sagayama, K., Tanaka, N., Fukumoto, T. et al. Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells. J Nat Med 73, 597–601 (2019). https://doi.org/10.1007/s11418-019-01280-0

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  • DOI: https://doi.org/10.1007/s11418-019-01280-0

Keywords

  • Inonotus obliquus
  • Chaga mushroom
  • Lanostane-type triterpene
  • Hair growth
  • Human follicle dermal papilla cell