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Appetite-enhancing effects of vanilla flavours such as vanillin


Vanilla flavour is familiar to consumers through foods, cosmetics, household products and some medicines. Vanilla flavouring agents typically contain vanillin or its analogue ethyl vanillin. Our previous study revealed that the inhalation of eugenol, which contains a vanillyl group, has an appetite-enhancing effect, and the inhalation of aroma compounds containing the vanillyl group or its analogues led to increased food intake in mice. Here, we found that vanillin, ethyl vanillin and eugenol showed appetite-enhancing effects, whereas isoeugenol and safrole did not. These results suggest that the appetite-enhancing effects could be attributable to the vanillyl group and could be affected by the position of the double bond in the aliphatic chain. Furthermore, the results of intraperitoneal administration of eugenol and vanillin suggest that their appetite-enhancing effects could occur via stimulation of olfactory receptors.

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  1. 1.

    Hotta M, Ogata K, Nitta A, Hoshikawa K, Yanagi M, Yamazaki K (1989) Useful plants of the world. Heibonsha, Tokyo

    Google Scholar 

  2. 2.

    Nishi T (1999) Shokubutsu-no hanashi arekore 7. Puranta 64:49–53

    Google Scholar 

  3. 3.

    Dignum MJW, Kerler J, Verpoorte R (2002) Vanilla curing under laboratory conditions. Food Chem 79:165–171

    CAS  Article  Google Scholar 

  4. 4.

    Ogawa K, Ito M (2016) Appetite-enhancing effects of curry oil. Biol Pharm Bull 39:1559–1563

    CAS  Article  Google Scholar 

  5. 5.

    Ito M, Toyoda M, Yuba A, Honda G (1999) Gentic analysis of nothoapiol formation in Perilla frutescens. Biol Pharm Bull 22:598–601

    CAS  Article  Google Scholar 

  6. 6.

    Duquensnoy E, Dinh NH, Castola V, Casanova J (2006) Composition of a pyrolytic oil from Cupressus funebris Endl. of Vietnamese origin. Flavour Fragr J 21:453–457

    Article  Google Scholar 

  7. 7.

    Choi HS, Kim MSL, Sawamura M (2002) Constituents of the essential oil of cnidium officinale Makino, a Korean medicinal plant. Flavour Fragr J 17:49–53

    CAS  Article  Google Scholar 

  8. 8.

    National Institute of Standards and Technology (2016) Trans-Isoeugenol. Accessed on 24 Feb 2018

  9. 9.

    National Institute of Standards and Technology (2016) Cis-Isoeugenol. Accessed on 24 Feb 2018

  10. 10.

    Ogawa K, Ito M (2016) Appetite-enhancing effects: the influence of concentrations of benzylacetone and trans-cinnamaldehyde and their inhalation time, as well as the effect of aroma, on body weight in mice. Biol Pharm Bull 39:794–798

    CAS  Article  Google Scholar 

  11. 11.

    Ogawa K, Ito M (2016) Appetite-enhancing effects of trans-cinnamaldehyde, benzylacetone and 1-phenyl-2-butanone by inhalation. Planta Med 82:84–88

    CAS  Article  Google Scholar 

  12. 12.

    Kajiya K, Inaki K, Tanaka M, Haga T, Kataoka H, Touhara K (2001) Molecular bases of odor discrimination: reconstitution of olfactory receptors that recognize overlapping sets of odorants. J Neurosci 21:6018–6025

    CAS  Article  Google Scholar 

  13. 13.

    Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661–671

    CAS  Article  Google Scholar 

  14. 14.

    Choi SJ, Ye SB, Na HG, Kim GO, Bae CH, Song SY, Kim YW, Park SY, Kim YD (2011) Effect of geranium essential oil on food intake via olfactory stimulus. Korean J Otorhinolaryngol Head Neck Surg 54:766–770

    Article  Google Scholar 

  15. 15.

    Yamamoto T, Inui T, Tsuji T (2013) The odor of Osmanthus fragrans attenuates food intake. Sci Rep 3:1518.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  16. 16.

    Cai X, Mai RZ, Zou JJ, Zhang HY, Zeng XL, Zheng RR, Wang CY (2014) Analysis of aroma-active compounds in three sweet osmanthus (Osmanthus fragrans) cultivars by GC-olfactometry and GC–MS. J Zhejiang Univ Sci B 15:348–638

    Article  Google Scholar 

  17. 17.

    Babu KGD, Kaul VK (2005) Variation in essential oil composition of rose-scented geranium (Pelargonium sp.) distilled by different distillation techniques. Flavour Fragr J 20:222–231

    CAS  Article  Google Scholar 

  18. 18.

    Higuchi Masaki (2016) EVERYDAY Sweets Mainichi tabetai, tsukuritai sweets recipes 100. Graphic-sha Publishing, Tokyo

    Google Scholar 

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Correspondence to Osamu Morinaga.

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Ogawa, K., Tashima, A., Sadakata, M. et al. Appetite-enhancing effects of vanilla flavours such as vanillin. J Nat Med 72, 798–802 (2018).

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  • Vanilla flavouring agents
  • Appetite-enhancing effects
  • Inhalation