Vanilla flavour is familiar to consumers through foods, cosmetics, household products and some medicines. Vanilla flavouring agents typically contain vanillin or its analogue ethyl vanillin. Our previous study revealed that the inhalation of eugenol, which contains a vanillyl group, has an appetite-enhancing effect, and the inhalation of aroma compounds containing the vanillyl group or its analogues led to increased food intake in mice. Here, we found that vanillin, ethyl vanillin and eugenol showed appetite-enhancing effects, whereas isoeugenol and safrole did not. These results suggest that the appetite-enhancing effects could be attributable to the vanillyl group and could be affected by the position of the double bond in the aliphatic chain. Furthermore, the results of intraperitoneal administration of eugenol and vanillin suggest that their appetite-enhancing effects could occur via stimulation of olfactory receptors.
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Hotta M, Ogata K, Nitta A, Hoshikawa K, Yanagi M, Yamazaki K (1989) Useful plants of the world. Heibonsha, Tokyo
Nishi T (1999) Shokubutsu-no hanashi arekore 7. Puranta 64:49–53
Dignum MJW, Kerler J, Verpoorte R (2002) Vanilla curing under laboratory conditions. Food Chem 79:165–171
Ogawa K, Ito M (2016) Appetite-enhancing effects of curry oil. Biol Pharm Bull 39:1559–1563
Ito M, Toyoda M, Yuba A, Honda G (1999) Gentic analysis of nothoapiol formation in Perilla frutescens. Biol Pharm Bull 22:598–601
Duquensnoy E, Dinh NH, Castola V, Casanova J (2006) Composition of a pyrolytic oil from Cupressus funebris Endl. of Vietnamese origin. Flavour Fragr J 21:453–457
Choi HS, Kim MSL, Sawamura M (2002) Constituents of the essential oil of cnidium officinale Makino, a Korean medicinal plant. Flavour Fragr J 17:49–53
National Institute of Standards and Technology (2016) Trans-Isoeugenol. http://webbook.nist.gov/cgi/cbook.cgi?ID=C5932683&Mask=200. Accessed on 24 Feb 2018
National Institute of Standards and Technology (2016) Cis-Isoeugenol. http://webbook.nist.gov/cgi/cbook.cgi?ID=5912-86-7. Accessed on 24 Feb 2018
Ogawa K, Ito M (2016) Appetite-enhancing effects: the influence of concentrations of benzylacetone and trans-cinnamaldehyde and their inhalation time, as well as the effect of aroma, on body weight in mice. Biol Pharm Bull 39:794–798
Ogawa K, Ito M (2016) Appetite-enhancing effects of trans-cinnamaldehyde, benzylacetone and 1-phenyl-2-butanone by inhalation. Planta Med 82:84–88
Kajiya K, Inaki K, Tanaka M, Haga T, Kataoka H, Touhara K (2001) Molecular bases of odor discrimination: reconstitution of olfactory receptors that recognize overlapping sets of odorants. J Neurosci 21:6018–6025
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404:661–671
Choi SJ, Ye SB, Na HG, Kim GO, Bae CH, Song SY, Kim YW, Park SY, Kim YD (2011) Effect of geranium essential oil on food intake via olfactory stimulus. Korean J Otorhinolaryngol Head Neck Surg 54:766–770
Yamamoto T, Inui T, Tsuji T (2013) The odor of Osmanthus fragrans attenuates food intake. Sci Rep 3:1518. https://doi.org/10.1038/srep01518
Cai X, Mai RZ, Zou JJ, Zhang HY, Zeng XL, Zheng RR, Wang CY (2014) Analysis of aroma-active compounds in three sweet osmanthus (Osmanthus fragrans) cultivars by GC-olfactometry and GC–MS. J Zhejiang Univ Sci B 15:348–638
Babu KGD, Kaul VK (2005) Variation in essential oil composition of rose-scented geranium (Pelargonium sp.) distilled by different distillation techniques. Flavour Fragr J 20:222–231
Higuchi Masaki (2016) EVERYDAY Sweets Mainichi tabetai, tsukuritai sweets recipes 100. Graphic-sha Publishing, Tokyo
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Ogawa, K., Tashima, A., Sadakata, M. et al. Appetite-enhancing effects of vanilla flavours such as vanillin. J Nat Med 72, 798–802 (2018). https://doi.org/10.1007/s11418-018-1206-x
- Vanilla flavouring agents
- Appetite-enhancing effects