Journal of Natural Medicines

, Volume 72, Issue 3, pp 798–802 | Cite as

Appetite-enhancing effects of vanilla flavours such as vanillin

  • Kakuyou Ogawa
  • Akira Tashima
  • Momoko Sadakata
  • Osamu Morinaga


Vanilla flavour is familiar to consumers through foods, cosmetics, household products and some medicines. Vanilla flavouring agents typically contain vanillin or its analogue ethyl vanillin. Our previous study revealed that the inhalation of eugenol, which contains a vanillyl group, has an appetite-enhancing effect, and the inhalation of aroma compounds containing the vanillyl group or its analogues led to increased food intake in mice. Here, we found that vanillin, ethyl vanillin and eugenol showed appetite-enhancing effects, whereas isoeugenol and safrole did not. These results suggest that the appetite-enhancing effects could be attributable to the vanillyl group and could be affected by the position of the double bond in the aliphatic chain. Furthermore, the results of intraperitoneal administration of eugenol and vanillin suggest that their appetite-enhancing effects could occur via stimulation of olfactory receptors.


Vanilla flavouring agents Appetite-enhancing effects Inhalation 


Compliance with ethical standards

Conflict of interest

The authors declare no conflicts of interest.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Kakuyou Ogawa
    • 1
  • Akira Tashima
    • 1
  • Momoko Sadakata
    • 1
  • Osamu Morinaga
    • 1
  1. 1.Department of Natural MedicinesDaiichi University of PharmacyFukuokaJapan

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