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Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

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Fomitopsis officinalis is a medicinal fungus, known as ‘Agarikon’, and is used traditionally in the treatment of asthma and rheumatism in Mongolia. The investigation of the chemical constituents of F. officinalis led to the isolation of 4 new lanostane triterpenoids together with 4 known triterpenoids. Inhibitory activity against Trypanosoma congolense, which causes fatal diseases in animals including livestock, was estimated for the isolated compounds. Compounds 25 and 8 exhibited moderate inhibition activities with IC50 values ranging from 7.0−27.1 µM.

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We thank Ms. Y. Matsushita, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, for assistance with the trypanocidal activity experiments, and Mr. S. Sato and Mr. T. Matsuki, Tohoku Medical and Pharmaceutical University, for assistance with the MS measurements. This work was supported by JICA M-JEED project and a grant from JSPS Kakenhi (Grant Number JP26860068). This work was partially supported by an Advanced Research Grant from the National University of Mongolia, the Kanno Foundation of Japan, a Cooperative Research Grant (28-joint-12, 29-joint-6) from the National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, and AMED/JICA SATREPS.

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Correspondence to Toshihiro Murata.

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Naranmandakh, S., Murata, T., Odonbayar, B. et al. Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity. J Nat Med 72, 523–529 (2018).

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