Anti-oral common pathogenic bacterial active acetylenic acids from Thesium chinense Turcz

  • Chang Liu
  • Xiao-Tian Li
  • Rong-Rong Cheng
  • Zhu-Zhen Han
  • Li Yang
  • Zhong-Chen Song
  • Zheng-Tao Wang
Original Paper

Abstract

Discovery of agents for oral infectious diseases is always encouraged in natural products chemistry. A bioassay-guided isolation led to the isolation of two new acetylenic acids (1, 2) along with seven known ones (39) from the ethanol extract of Thesium chinense Turcz, a commonly used oral anti-bacterial and anti-inflammatory herb. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Exocarpic acid (3) demonstrated the most promising activity against three tested oral pathogenic bacterial strains, Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus mutans, with minimum inhibitory concentration values of 0.86, 3.43, and 13.70 μg/mL, respectively. Compounds 1, 2, 4, 5 and 7 also showed potential activities against periodontal bacteria (P. gingivalis, F. nucleatum).

Keywords

Acetylenic acids Thesium chinense Anti-oral pathogenic bacterial activity 

Notes

Acknowledgments

This work was financially supported by the Shanghai Science and Technology Development Foundation (17XD1403500).

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  • Chang Liu
    • 1
  • Xiao-Tian Li
    • 2
    • 3
  • Rong-Rong Cheng
    • 1
  • Zhu-Zhen Han
    • 1
  • Li Yang
    • 1
  • Zhong-Chen Song
    • 2
    • 3
  • Zheng-Tao Wang
    • 1
  1. 1.The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia MedicaShanghai University of Traditional Chinese MedicineShanghaiChina
  2. 2.Department of Periodontology, Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina
  3. 3.Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of StomatologyNational Clinical Research Center of StomatologyShanghaiChina

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