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Agelamasines A and B, diterpene alkaloids from an Okinawan marine sponge Agelas sp.

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Abstract

Two new diterpene alkaloids having an N-methyladenine moiety, agelamasines A (1) and B (2), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1 and 2 were elucidated on the basis of spectroscopic analyses. Agelamasine A (1) is the first diterpene alkaloid with a rearranged (4 → 2)-abeo-clerodane skeleton from a marine source, while agelamasine B (2) is a clerodane diterpene alkaloid.

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Acknowledgements

We thank Mr. Z. Nagahama for his help with the sponge collection. This work was partly supported by JSPS KAKENHI Grant number JP17K08337.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Tokushima University, Tokushima, 770-8505, Japan

    Sanghoon Lee, Naonobu Tanaka & Yoshiki Kashiwada

  2. Graduate School of Bioscience and Bioindustry, Tokushima University, Tokushima, 770-8513, Japan

    Naonobu Tanaka

  3. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan

    Jun’ichi Kobayashi

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  1. Sanghoon Lee
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  2. Naonobu Tanaka
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  3. Jun’ichi Kobayashi
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  4. Yoshiki Kashiwada
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Corresponding authors

Correspondence to Naonobu Tanaka or Yoshiki Kashiwada.

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Lee, S., Tanaka, N., Kobayashi, J. et al. Agelamasines A and B, diterpene alkaloids from an Okinawan marine sponge Agelas sp.. J Nat Med 72, 364–368 (2018). https://doi.org/10.1007/s11418-017-1157-7

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  • DOI: https://doi.org/10.1007/s11418-017-1157-7

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