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Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan

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Abstract

Two new stilbenoid dimers, cajanstilbenoids A (1) and B (2), were isolated from the leaves of Cajanus cajan. Planar structures of these compounds were verified by NMR (1D and 2D) and high-resolution electrospray ionization mass spectroscopy (HR-ESI–MS). Absolute configurations were assigned by comparing experimental and calculated electronic CD values. The cytotoxicity of 1 and 2 against human hepatoma (HepG2), human breast adenocarcinoma (MCF-7), and human lung cancer (A549) cells were evaluated in vitro. Compound 1 showed strong cytotoxicity against all the tested cell lines (IC50 values: 2.14–2.56 µM), whereas compound 2 showed strong toxicity only against HepG2 (IC50 value: 5.99 µM) and A549 cells (IC50 value: 6.18 µM).

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Acknowledgements

This study was supported by the National Undergraduate Training Programs for Innovation and Entrepreneurship (No. 201610660024), Project of Health and Family Planning Committee of Guizhou Province (No. gzwjkj2014-2-103), Joint Fund of the Department of Science and Technology of Guizhou Province and Guizhou Medical University (No. LH [2015]7339), and Fund of the Innovation Team of Guizhou Province (No. 2015-4025).

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Authors and Affiliations

  1. Pharmacy College of Guizhou Medical University, University Town, Gui’an New District, Guiyang, 550025, China

    Nenling Zhang & Xiangchun Shen

  2. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou, 510650, China

    Nenling Zhang, Xiaofei Jiang & Samuel X. Qiu

  3. Guangzhou University of Chinese Medicine, Guangzhou, 510006, China

    Jiazhong Cai, Xiaoling Shen & Yingjie Hu

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  1. Nenling Zhang
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  2. Xiangchun Shen
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  3. Xiaofei Jiang
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  4. Jiazhong Cai
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  5. Xiaoling Shen
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  7. Samuel X. Qiu
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Correspondence to Nenling Zhang.

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Zhang, N., Shen, X., Jiang, X. et al. Two new cytotoxic stilbenoid dimers isolated from Cajanus cajan . J Nat Med 72, 304–309 (2018). https://doi.org/10.1007/s11418-017-1138-x

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