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New ellagitannins from Tiencha and their inhibitory activity against dental plaque

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Abstract

Four new galloyl-oxygen-diphenyl (GOD)-type ellagitannins, brambliins A–D (1–4), were isolated from the leaves of Rubus suavissimus. Their structures were elucidated by extensive spectroscopic analyses and the absolute configurations of 1–4 were determined by chemical and phytochemical evidence. These GOD-type ellagitannins inhibited the formation of dental plaque, which is beneficial for oral hygiene.

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Acknowledgements

We are grateful to Prof. Yoshiki Kashiwada and Mr. Kanji Niwa of Tokushima University for the measurement of CD spectra for structure determination. We also thank Prof. Xia Nianhe of South China Botanical Garden for plant determination.

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Authors and Affiliations

  1. Maruzen Pharmaceuticals Co.Ltd., 1089-8 Sagata, Shin-ichi, Fukuyama, Hiroshima, 729-3102, Japan

    Fusako Nakano, Shozo Miyoshi & Toshiyuki Murakami

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  1. Fusako Nakano
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  2. Shozo Miyoshi
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  3. Toshiyuki Murakami
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Correspondence to Fusako Nakano.

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Nakano, F., Miyoshi, S. & Murakami, T. New ellagitannins from Tiencha and their inhibitory activity against dental plaque. J Nat Med 71, 545–552 (2017). https://doi.org/10.1007/s11418-017-1090-9

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  • DOI: https://doi.org/10.1007/s11418-017-1090-9

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