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Journal of Natural Medicines

, Volume 71, Issue 1, pp 329–333 | Cite as

Hypouricemic effect of flaccidoside II in rodents

  • Guo-bin Zhang
  • Shan-shan Ren
  • Bao-ying Wang
  • Lian-qi Tian
  • Fei-hong Bing
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  • 156 Downloads

Abstract

To investigate the effect of flaccidoside II on the serum uric acid levels in hyperuricemic rodents. Both mice and rats were injected intraperitoneally with potassium oxonate to induce hyperuricemia. Different dosages of flaccidoside II were orally administrated to hyperuricemic and normal rodents for 7 days, respectively. Liver xanthine oxidase (XOD) activities in hyperuricemic mice were determined using the colorimetric method. Acute toxicity of flaccidoside II was also evaluated in mice. Allopurinol, as a positive control, was administered under the same treatment scheme. The results showed that flaccidoside II (32, 16 and 8 mg/kg) could significantly lower serum uric acid levels in hyperuricemic mice. Flaccidoside II (24, 12 and 6 mg/kg) could also markedly lower serum uric acid levels in hyperuricemic rats. However, unlike allopurinol, oral administration of flaccidoside II did not produce any observable hypouricemic effect in normal animals. Flaccidoside II at the dose of 32 mg/kg significantly suppressed XOD activities in the liver of hyperuricemic mice, while at doses of 16 and 8 mg/kg flaccidoside II did not show a significant effect on XOD activities. In addition, flaccidoside II (300 mg/kg) has no or less toxicity than allopurinol in mice. These findings demonstrate that flaccidoside II exhibits anti-hyperuricemic activity in hyperuricemic animals.

Keywords

Flaccidoside II Uric acid Hyperuricemia Xanthine oxidase Rodent 

Notes

Acknowledgments

This study was supported by the Program for Science and Technology Innovation Talents in Universities of Henan Province (15HASTIT041), Foundation of He’nan Educational Committee (14A360010), Fundamental Research Funds for He’nan University of TCM (2014KYYWF-QN20) and the Program for STITHCCM (2014XCXRC02).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  • Guo-bin Zhang
    • 1
  • Shan-shan Ren
    • 2
  • Bao-ying Wang
    • 2
  • Lian-qi Tian
    • 1
  • Fei-hong Bing
    • 3
  1. 1.Pharmacy CollegeHe’nan University of Traditional Chinese MedicineZhengzhouChina
  2. 2.Department of Science and TechnologyHe’nan University of Traditional Chinese MedicineZhengzhouChina
  3. 3.Wuhan Daoyitang Hospital of Traditional Chinese MedicineWuhanChina

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