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Two new diterpenoids from Leonotis leonurus R. Br.

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Abstract

Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.

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Acknowledgments

This work was supported in part by MEXT-Supported Program for the Strategic Research Foundation at Private Universities and Keio Gijuku Academic Development Funds.

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Authors and Affiliations

  1. Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-Ku, Tokyo, 105-8512, Japan

    Yuji Narukawa, Miyuki Komori, Akiko Niimura, Hitomi Noguchi & Fumiyuki Kiuchi

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  1. Yuji Narukawa
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  2. Miyuki Komori
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  3. Akiko Niimura
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  4. Hitomi Noguchi
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  5. Fumiyuki Kiuchi
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Correspondence to Fumiyuki Kiuchi.

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Narukawa, Y., Komori, M., Niimura, A. et al. Two new diterpenoids from Leonotis leonurus R. Br.. J Nat Med 69, 130–134 (2015). https://doi.org/10.1007/s11418-014-0868-2

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  • DOI: https://doi.org/10.1007/s11418-014-0868-2

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