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Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances

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Abstract

A new aaptamine class alkaloid, designated 2-methoxy-3-oxoaaptamine (1), together with seven known aaptamines (2–8) were isolated from a marine sponge of Aaptos sp. as anti-mycobacterial substances against active and dormant bacilli. The chemical structure of 1 was determined on the basis of spectroscopic analysis. Compound 1 was anti-mycobacterial against Mycobacterium smegmatis in both active growing and dormancy-inducing hypoxic conditions with a minimum inhibitory concentration (MIC) of 6.25 μg/ml, and compounds 2, 5, 6, and 7 showed anti-mycobacterial activities under hypoxic condition selectively, with MIC values of 1.5–6.25 μg/ml.

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Acknowledgments

This study was financially supported by the Hoansha Foundation and Grant-in-Aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Osaka University, Yamada-oka 1-6, Suita, Osaka, 565-0871, Japan

    Masayoshi Arai, Chisu Han, Yoshi Yamano & Motomasa Kobayashi

  2. Department of Chemistry, Faculty of Science, Lampung University, Jl. Prof. Dr. Sumantri Brodjonegoro No. 1, Tanjungkarang, 35145, Indonesia

    Andi Setiawan

Authors
  1. Masayoshi Arai
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  2. Chisu Han
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  3. Yoshi Yamano
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  4. Andi Setiawan
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  5. Motomasa Kobayashi
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Correspondence to Masayoshi Arai or Motomasa Kobayashi.

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Arai, M., Han, C., Yamano, Y. et al. Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances. J Nat Med 68, 372–376 (2014). https://doi.org/10.1007/s11418-013-0811-y

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  • DOI: https://doi.org/10.1007/s11418-013-0811-y

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