Abstract
Three new apotirucallanes (1–3) were isolated from the leaves of Walsura trichostemon. Their structures were identified by interpretation of their spectroscopic data as well as comparison with those reported in the literature. In addition, all isolated compounds were evaluated for their cytotoxicity against KB and HeLa cells.
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References
Yin S, Wang X-N, Fan C-Q, Liao S-G, Yue J-M (2007) The first limonoid peroxide in the meliaceae family: Walsuronoid A from Walsura robusta. Org Lett 9:2353–2356
Zhou Z-W, Yin S, Zhang H-Y, Fu Y, Yang S-P, Wang X-N, Wu Y, Tang X-C, Yue J-M (2008) Walsucochins A and B with an unprecedented skeleton isolated from Walsura cochinchinensis. Org Lett 10:465–468
Sichaem J, Aree T, Khumkratok S, Jong-Aramruang J, Tip-Pyang S (2012) A new cytotoxic apotirucallane from the roots of Walsura trichostemon. Phytochem Lett 5:665–667
Sichaem J, Surapinit S, Siripong P, Khumkratok S, Jong-Aramruang J, Tip-Pyang S (2010) Two new cytotoxic isomeric indole alkaloids from the roots of Nauclea orientalis. Fitoterapia 81:830–833
Sichaem J, Ruksilp T, Worawalai W, Siripong P, Khumkratok S, Tip-Pyang S (2011) A new dimeric aporphine from the roots of Artabotrys spinosus. Fitoterapia 82:422–425
Sichaem J, Kaennakam S, Siripong P, Tip-Pyang S (2012) Tabebuialdehydes A–C, cyclopentene dialdehyde derivatives from the roots of Tabebuia rosea. Fitoterapia 83:1456–1459
Luo X-D, Wu S-H, Ma Y-B, Wu D-G (2000) Tetranortriterpenoids from Walsura yunnanensis. J Nat Prod 63:947–951
Dong S-H, Liu J, Ge Y-Z, Dong L, Xu C-H, Ding J, Yue J-M (2013) Chemical constituents from Brucea javanica. Phytochemistry 85:175–184
Xie BJ, Yang SP, Chen HD, Yue JM (2007) Agladupols A-E, triterpenoids from Aglaia duperreana. J Nat Prod 70:1532–1535
Kongkathip N, Kongkathip B, Siripong P, Sangma C, Luangkamin S, Niyomdecha M, Pattanapa S, Piyaviriyagul S, Kongsaeree P (2003) Potent antitumor activity of synthetic 1,2-naphthoquinones and 1,4-naphthoquinones. Bioorg Med Chem 11:3179–3191
Acknowledgments
The authors are grateful to the Graduate School of Chulalongkorn University for a Postdoctoral Fellowship (Ratchadaphiseksomphot Endowment Fund) to JS, the Higher Education Research Promotion and National Research University Project of Thailand, the Office of the Higher Education Commission, and the Ratchadaphiseksomphot Endowment Fund (FW645A) for partially supporting this project. We also thank Dr. Christopher Smith of the Department of Chemistry, Faculty of Science, Chulalongkorn University, for his editorial comments.
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Sichaem, J., Khumkratok, S., Siripong, P. et al. New cytotoxic apotirucallanes from the leaves of Walsura trichostemon . J Nat Med 68, 436–441 (2014). https://doi.org/10.1007/s11418-013-0808-6
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DOI: https://doi.org/10.1007/s11418-013-0808-6