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Three acetophenones from Acronychia pedunculata

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Abstract

Phytochemical investigation of the leaves and twigs of Acronychia pedunculata has led to the isolation of three new acetophenone monomers 1–3 as well as 1-[2′,4′-dihydroxy-3′,5′-di-(3″-methyl-2″-butenyl)-6′-methoxy]phenylethanone (4), acronyculatin E (5), a mixture of β-sitosterol and stigmasterol, and sesamin. The structures of these new compounds were elucidated spectroscopically. The inhibitory activities of the isolated acetophenone derivatives against mammalian DNA polymerases and human cancer cell growth were also assessed.

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Acknowledgments

This research was financially supported by the Kobe Pharmaceutical University Collaboration Fund. Thanks are also due to Dr. C. Tode (Kobe Pharmaceutical University) for 1H- and 13C-NMR spectra, and to Dr. A. Takeuchi (Kobe Pharmaceutical University) for mass spectrum measurements.

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Authors and Affiliations

  1. Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe, 658-8558, Japan

    Sachiko Kozaki, Yukiko Takenaka & Takao Tanahashi

  2. Laboratory of Food and Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi-ku, Kobe, Hyogo, 651-2180, Japan

    Yoshiyuki Mizushina

  3. The Nippon Shinyaku Institute for Botanical Research, 39, Sakanotsuji-cho, Oyake, Yamashina-ku, Kyoto, 607-8182, Japan

    Takao Yamaura

Authors
  1. Sachiko Kozaki
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  2. Yukiko Takenaka
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  3. Yoshiyuki Mizushina
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  4. Takao Yamaura
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  5. Takao Tanahashi
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Corresponding author

Correspondence to Takao Tanahashi.

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Kozaki, S., Takenaka, Y., Mizushina, Y. et al. Three acetophenones from Acronychia pedunculata . J Nat Med 68, 421–426 (2014). https://doi.org/10.1007/s11418-013-0803-y

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  • DOI: https://doi.org/10.1007/s11418-013-0803-y

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