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Journal of Natural Medicines

, Volume 67, Issue 4, pp 719–724 | Cite as

Improvement in blood fluidity by Kaempferia parviflora rhizome

  • Kazuya Murata
  • Takahiro Deguchi
  • Takanori Fujita
  • Hideaki Matsuda
Original Paper

Abstract

Improvement in blood fluidity leads to the prevention of various lifestyle-related diseases. A raw material for improving blood fluidity has been long desired in the research area of functional and supplemental foods. We successfully showed an improvement in blood fluidity by the Zingiberaceae plant, Kaempferia parviflora. The rhizome of the plant reduced the blood passage time through a micro slit using a disseminated intravascular coagulation model. The mechanism was attributed to the activation of fibrinolysis, as demonstrated by elongation of the euglobulin lysis time and an in-vitro fibrinolysis assay. The active principles were determined to be methoxyflavones. The results show that the rhizome of K. parviflora is a promising candidate preventive agent for treating lifestyle-related diseases.

Keywords

Kaempferia parviflora Fibrinolysis Euglobulin lysis time Disseminated intravascular coagulation Methoxyflavones Fibrinolytic area assay 

Notes

Acknowledgments

This study was financially supported by the “Antiaging Center Project” for Private Universities from the Ministry of Education, Culture, Sports, Science and Technology, 2008–2012.

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Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2012

Authors and Affiliations

  • Kazuya Murata
    • 1
  • Takahiro Deguchi
    • 1
  • Takanori Fujita
    • 2
  • Hideaki Matsuda
    • 1
  1. 1.Faculty of PharmacyKinki UniversityHigashiosakaJapan
  2. 2.Japan Tablet CorporationUjiJapan

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