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Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice

Abstract

The present study investigated the gastroprotective effects of a cinnamon diet using different gastric ulcer mouse models. Dose dependency and the effective dose period of administration of a cinnamon powder diet were established using the water immersion stress gastric ulcer model. A cinnamon powder diet significantly protected mice against ulceration by stress, ethanol, HCl and oral administration of aspirin, but not against ulceration by oral administration of indomethacin or subcutaneous administration of indomethacin or aspirin. Such a diet conferred protection against gastric ulcers at an effective concentration of 100 mg cinnamon powder per gram of food after administration for 4 weeks and the active compound of cinnamon powder for gastroprotective activity was identified as cinnamaldehyde. These findings indicate that regular ingestion of cinnamon powder offers gastroprotection presumably through a cytoprotective mechanism but the efficacy against NSAIDs-induced gastric ulcers may be limited.

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Acknowledgments

This work was funded by Takeda Science Foundation (2009 grant), Kyoto, Japan.

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Correspondence to Michiho Ito.

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Supplementary Figure 1

. Pictomicrograph showing thickened mouse gastric mucosa after completion of the 4-week cinnamon powder diet. A, Cinnamon-treated group. B, Control group. Scale bar, 100 μm. (TIFF 1202 kb)

Supplementary Figure 2

. Chemical fingerprints of EACC (A), fraction 1 (B), fraction 2 (C) and fraction 3 (D). Peaks 1, unidentified; 2, cinnamylalcohol; 3, coumarin; 4, cinnamaldehyde; 5, eugenol; 6, cinnamyl acetate; 7, unidentified. HPLC conditions: Column pack: ODS/R: 10 μl, 120 A, 4.6 × 250 mm. I.D. Program: 37 % MeOH (at 0 min) – 100 % MeOH (at 30 min). Flow Rate: 1 ml/min. Injection volume: 3 μl. Detection: UV 254 nm. (TIFF 671 kb)

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Tankam, J.M., Sawada, Y. & Ito, M. Regular ingestion of cinnamomi cortex pulveratus offers gastroprotective activity in mice. J Nat Med 67, 289–295 (2013). https://doi.org/10.1007/s11418-012-0680-9

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Keywords

  • Cinnamomum cassia powder
  • Gastric ulcer
  • Gastroprotection
  • Regular ingestion
  • Synergism