Abstract
The inhibitory effects of the ethyl acetate extract and capsaicin (1) and dihydrocapsaicin (2) isolated from fruits of Capsicum annuum chili pepper type, and synthetic capsaicinoid derivatives (N-(4-hydroxyphenylethyl)decamide (3), (E)-N-(4-hydroxy-3-methoxybenzyl)-3,7-dimethylocta-2,6-dienamide (4), 4-hydroxy-3-methoxy-N-((E)-3,7-dimethylocta-2,6-dienyl)benzamide (5) and N-(4-hydroxy-3-methoxybenzyl)decamide (6) at different concentrations were evaluated against Streptococcus mutans. The minimum inhibitory concentration at which the ethyl acetate extract prevented the growth of S. mutans was 2.5 mg/mL; those of the isolated compounds 1 and 2 were 1.25 μg/mL, while 3 was 5.0 μg/mL, and 4, 5 and 6 were 2.5 μg/mL, respectively.
This is a preview of subscription content, log in via an institution to check access.
References
Moreira GR, Caliman FRB, Silva DJH, Ribeiro CSC (2006) Espécies e variedades de pimenta. Informe Agropecuário 27:16–29
Pinto CMF, Puiatti M, Caliman FRB, Moreira GR, Mattos RN (2006) Clima, época de semeadura, produção de mudas, plantio e espaçamento na cultura da pimenta. Informe Agropecuário 27:40–49
Dorantes L, Colmenero R, Hernandez H, Mota L, Jaramillo ME, Fernandez E, Solano C (2000) Inhibition of growth of some foodborne pathogenic bacteria by Capsicum annuum extracts. Int J Food Microbiol 57:125–128
Careaga M, Fernández E, Dorantes L, Mota L, Jaramillo ME, Hernandez-Sanchez H (2003) Antibacterial activity of Capsicum annuum extract against Salmonella typhimurium and Pseudomonas aeruginosa inoculated in raw beef meat. Int J Food Microbiol 83:331–335
Iwaki K, Koya-Miyata S, Kohno K, Ushio S, Fukuda S (2006) Antimicrobial activity of Polygonum tinctorium Lour: extract against oral pathogenic bacteria. J Nat Med 60:121–125
Santos MMP (2010) Atividade antimicrobiana in vitro de extratos vegetais das espécies Mangifera indica, Eugenia jambolana, Schinus terebinthifolius, Capsicum annuum, e de análogos da capsaicina, frente aos microorganismos da cavidade oral. Ph.D. thesis, Universidade Estadual do Norte Fluminense, Brazil
Gonçalves PS (2009) Síntese de análogos de capsaicina e nova síntese da dihidrocapsaicina como potenciais substâncias antibacterianas. M.Sc. thesis, Universidade Estadual do Norte Fluminense, Brazil
Baratieri LN (1992) Dentística, procedimentos preventivos e restauradores, 2a Ed. Quintessence, São Paulo, Brazil
Forssten SD, Björklund M, Ouwehand AC (2010) Streptococcus mutans, caries and simulation models. Nutrients 2:290–298
Eguchi Y, Kubo N, Matsunaga H, Igarashi M, Utsumi R (2011) Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C. Antimicrob Agents Chemother 55:1475–1484
Coog GS, Costerton JW, Lamont RJ (1998) Biofilm formation by Porphyromonas gingivalis and Streptococcus gordonii. J Periodontal Res 33:323–327
Acknowledgments
The authors are grateful to Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) for financial support and grants to Conselho Nacional de Desenvolvimento Científico (CNPq-Brazil) for a research fellowship and grants.
Author information
Authors and Affiliations
Corresponding author
Additional information
I.J.C. Vieira, M.M.P. Santos and O.V. Motta contributed equally to this work.
Rights and permissions
About this article
Cite this article
Santos, M.M.P., Vieira-da-Motta, O., Vieira, I.J.C. et al. Antibacterial activity of Capsicum annuum extract and synthetic capsaicinoid derivatives against Streptococcus mutans . J Nat Med 66, 354–356 (2012). https://doi.org/10.1007/s11418-011-0579-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11418-011-0579-x