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A new iridoid glycoside and NO production inhibitory activity of compounds isolated from Russelia equisetiformis

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Abstract

From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Russelia equisetiformis, one new iridoid glucoside was isolated along with 24 known compounds, comprising iridoids and iridoid glucosides, phenyl propane glucosides, phenyl ethanoids, lignan glucosides, and flavonoid glucosides. The structure of the new compound was elucidated to be 10-O-cinnamoyl sinuatol. Of the 25 compounds isolated, rehmaglutin B exhibited moderate inhibitory activity toward NO production, which was not associated with cytotoxicity.

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Acknowledgments

The authors are grateful for access to the superconducting NMR instrument and the HR-ESI-MS at the Analytical Center of Molecular Medicine and the Analysis Center of Life Science, respectively, of the Graduate School of Biomedical Sciences, Hiroshima University. This work was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports, Culture and Technology of Japan, and the Japan Society for the Promotion of Science (nos. 22590006 and 23590130). Thanks are also due to the Takeda Science Foundation for financial support.

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Authors and Affiliations

  1. Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Madoka Ochi, Katsuyoshi Matsunami & Hideaki Otsuka

  2. Faculty of Pharmacy, Yasuda Women’s University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan

    Yoshio Takeda

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  1. Madoka Ochi
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  2. Katsuyoshi Matsunami
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Correspondence to Hideaki Otsuka.

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Ochi, M., Matsunami, K., Otsuka, H. et al. A new iridoid glycoside and NO production inhibitory activity of compounds isolated from Russelia equisetiformis . J Nat Med 66, 227–232 (2012). https://doi.org/10.1007/s11418-011-0569-z

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