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Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats

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Abstract

The hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves was studied in Triton WR-1339- and high fat diet-induced hyperlipidemic rats. In Triton WR-1339-induced hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) exerted a significant (P < 0.01) lipid-lowering effect compared to ethyl acetate and methanol extracts, as assessed by the reversal of the plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). In high fat diet-fed hyperlipidemic rats, the hexane extract (250 and 500 mg/kg) caused the lowering of lipid levels in the plasma and liver. The hypolipidemic activity of S. cochinchinensis leaves was compared with fenofibrate, a known lipid-lowering drug, in both models.

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Acknowledgments

The authors are grateful to the Entomology Research Institute, Chennai, India, for the financial assistance.

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Authors and Affiliations

  1. Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai, 600 034, India

    Christudas Sunil

  2. Department of Life Sciences, School of Pharmacy and Health Sciences, International Medical University, Kuala Lumpur, Malaysia

    Chidambaram Kumarappan

  3. Entomology Research Institute, Loyola College, Chennai, 600 034, India

    Savarimuthu Ignacimuthu

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  1. Christudas Sunil
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  2. Savarimuthu Ignacimuthu
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  3. Chidambaram Kumarappan
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Correspondence to Savarimuthu Ignacimuthu.

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Sunil, C., Ignacimuthu, S. & Kumarappan, C. Hypolipidemic activity of Symplocos cochinchinensis S. Moore leaves in hyperlipidemic rats. J Nat Med 66, 32–38 (2012). https://doi.org/10.1007/s11418-011-0548-4

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  • DOI: https://doi.org/10.1007/s11418-011-0548-4

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