Journal of Natural Medicines

, Volume 65, Issue 3–4, pp 532–543 | Cite as

Adaptogenic potential of curcumin in experimental chronic stress and chronic unpredictable stress-induced memory deficits and alterations in functional homeostasis

  • Nitish Bhatia
  • Amteshwar Singh Jaggi
  • Nirmal SinghEmail author
  • Preet Anand
  • Ravi Dhawan
Original Paper


The present study was designed to investigate the role of curcumin in chronic stress and chronic unpredictable stress-induced memory deficits and alteration of functional homeostasis in mice. Chronic stress was induced by immobilizing the animal for 2 h daily for 10 days, whereas chronic unpredictable stress was induced by employing a battery of stressors of variable magnitude and time for 10 days. Curcumin was administered to drug-treated mice prior to induction of stress. Body weight, adrenal gland weight, ulcer index and biochemical levels of glucose, creatine kinase, cholesterol, corticosterone, thiobarbituric acid reactive substances (TBARS) and reduced glutathione (GSH) were evaluated to assess stress-induced functional changes. Memory deficits were evaluated using the elevated plus maze (EPM) model. Chronic stress and chronic unpredictable stress significantly increased the levels of corticosterone, glucose and creatine kinase and decreased cholesterol levels. Moreover, chronic stress and chronic unpredictable stress resulted in severe memory deficits along with adrenal hypertrophy, weight loss and gastric ulceration. Chronic stress and chronic unpredictable stress also increased oxidative stress assessed in terms of increase in TBARS and decrease in GSH levels. Pretreatment with curcumin (25 and 50 mg/kg p.o.) attenuated chronic stress and chronic unpredictable stress-associated memory deficits, biochemical alterations, pathological outcomes and oxidative stress. It may be concluded that curcumin-mediated antioxidant actions and decrease in corticosterone secretion are responsible for its adaptogenic and memory restorative actions in chronic and chronic unpredictable stress.


Curcumin Chronic stress Chronic unpredictable stress Immobilization Oxidative stress 



The authors are grateful to the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India, for supporting this study and providing technical facilities for the work.


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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2011

Authors and Affiliations

  • Nitish Bhatia
    • 1
  • Amteshwar Singh Jaggi
    • 1
  • Nirmal Singh
    • 1
    Email author
  • Preet Anand
    • 2
  • Ravi Dhawan
    • 3
  1. 1.Department of Pharmaceutical Sciences and Drug ResearchPunjabi UniversityPatialaIndia
  2. 2.Department of ChemistryPunjabi UniversityPatialaIndia
  3. 3.Khalsa College of PharmacyAmritsarIndia

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