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Laevigatbenzoate from Croton laevigatus Vahl.

Journal of Natural Medicines volume 65, pages 391–394 (2011)Cite this article

Abstract

A new trans-clerodane diterpenoid, laevigatbenzoate (1), was isolated from the leaves of Croton laevigatus Vahl. Its structure was established on the basis of spectroscopic analysis, and the absolute configuration was determined by application of the CD excitation chirality method. This compound showed weak cytotoxicity against HeLa cells, with an IC50 value of 45.4 μM.

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Acknowledgments

We gratefully acknowledge financial support from the Major Project of Chinese National Programs for Severe Infectious Diseases (2008ZX10003-006), National Natural Science Foundation of China (Grant No. 30900124), and the National S&T Major Special Project on Major New Drug Innovation (2009ZX09301-003). We also thank the staff of the Analytical Center, Beijing Institute of Microchemistry, China, for the measurements of NMR and mass spectra.

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Affiliations

  1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, People’s Republic of China

    Guo-An Zou, Hong-Wu Zhang, Jun-Shan Yang, Chao-Zhong Peng & Zhong-Mei Zou

  2. Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Ürümqi, 830011, People’s Republic of China

    Guo-An Zou & Haji Akber Aisa

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  1. Guo-An Zou
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  2. Hong-Wu Zhang
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  3. Haji Akber Aisa
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  4. Jun-Shan Yang
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  6. Zhong-Mei Zou
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Correspondence to Zhong-Mei Zou.

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Zou, GA., Zhang, HW., Aisa, H.A. et al. Laevigatbenzoate from Croton laevigatus Vahl.. J Nat Med 65, 391–394 (2011). https://doi.org/10.1007/s11418-010-0503-9

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  • DOI: https://doi.org/10.1007/s11418-010-0503-9

Keywords

  • Croton laevigatus Vahl.
  • Euphorbiaceae
  • Diterpenoid
  • Laevigatbenzoate
  • Cytotoxicity