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Constituents of cultivated Agaricus blazei

Journal of Natural Medicines volume 65, pages 307–312 (2011)Cite this article

Abstract

Two phenylhexane derivatives (1, 2), benzoylergostane (3), N-benzoyl-l-leucine methyl ester (4), two known ergostanes, and highly degraded incisterol were isolated from fruit bodies of Agaricus blazei. Compound 3 exhibited strong cytotoxicity toward HepG2 cells (IC50 = 6.0 ± 0.33 μM).

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Fig. 1
Fig. 2

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Acknowledgments

The authors thank Marukura Co., Ltd (Onojo City, Fukuoka) for supplying the fruiting bodies of Agaricus blazei. The authors are grateful for access to the superconducting NMR instrument at the Analytical Center of Molecular Medicine of the Graduate School of Biomedical Sciences, Hiroshima University, and an Applied Biosystem QSTAR XL system ESI (Nano Spray)–TOF–MS at the Analytical Center of Molecular Medicine and the Analysis Center of Life Science, respectively, of the Hiroshima University Faculty of Medicine.

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Affiliations

  1. Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Yumi Ueguchi, Katsuyoshi Matsunami & Hideaki Otsuka

  2. Division of Novel Food and Immunochemistry, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, 158-8501, Japan

    Kazunari Kondo

Authors
  1. Yumi Ueguchi
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  2. Katsuyoshi Matsunami
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  3. Hideaki Otsuka
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  4. Kazunari Kondo
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Correspondence to Hideaki Otsuka.

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Ueguchi, Y., Matsunami, K., Otsuka, H. et al. Constituents of cultivated Agaricus blazei . J Nat Med 65, 307–312 (2011). https://doi.org/10.1007/s11418-010-0495-5

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Keywords

  • Agaricus blazei
  • Basidomycota
  • Agaricaceae
  • Phenylhexane
  • Ergostane
  • Cytotoxicity