Journal of Natural Medicines

, Volume 64, Issue 4, pp 487–491 | Cite as

Clinical effectiveness of KSS formula, a traditional folk remedy for alcohol hangover symptoms

  • Mizuho Takahashi
  • Wei Li
  • Kazuo Koike
  • Kiyomi Sadamoto
Note

Abstract

A formula (KSS formula) containing the pith of Citrus tangerine Hort. et Tanaka (Kitsuraku), the rhizome of Zingiber officinale (Shokyo), and brown sugar has been traditionally used in China for the treatment of discomfort and cold sensation in the abdomen after ingestion of large amounts of alcohol. We evaluated the clinical effectiveness of this formula on signs and symptoms of alcohol hangover (AH). Of the twenty-two symptoms listed, significant decreases in severity scores were shown in nausea, vomiting, and diarrhea when the formula was administered in scheduled prophylactic doses. The score in overall well-being, ranging from 0 to 100 (worst possible condition), was 68.9 ± 16.5 (mean ± SD) in the control group and it decreased to 46.9 ± 27.3 and to 44.4 ± 26.4 in the two groups that included a dosing point prior to alcohol ingestion. Regardless of dosing schedules, KSS formula did not alter the time required for complete recovery from AH symptoms. These findings suggest the possibility that KSS formula may become a candidate for AH remedy when administered prophylactically.

Keywords

Alcohol hangover Remedy Prevention Clinical effectiveness Assessment 

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Copyright information

© The Japanese Society of Pharmacognosy and Springer 2010

Authors and Affiliations

  • Mizuho Takahashi
    • 1
  • Wei Li
    • 1
  • Kazuo Koike
    • 1
  • Kiyomi Sadamoto
    • 1
  1. 1.Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan

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