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Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine-induced in rats

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Abstract

The aim of this study is to investigate effects of Flos lonicera extract (FLE) on acute liver injury model rats which induced by 35 mg/kg dimethylnitrosamine (DMN). Model rats were divided into hepatic injury control group (administrated with water), FLE group (administrated with FLE) and silymarin group (administrated with silymarin which is hepatotherapeutic drug) as positive control. They were examined including ALT, AST, ALP, γ-GT, ALB and TP levels in serum, and MDA, GPx levels in liver tissue. In addition, pathologic changes, particularly fibrosis, were examined by Azan staining. The results revealed that the ALT, AST, ALP, γ-GT, MDA GPx and liver fibrosis degree in the LJE group were lower than the silymarin group and control group, ALB and TP were higher than the silymarin group and control group. These results suggested that LJE may help in inhibiting of acute liver injury greater than silymarin.

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Authors and Affiliations

  1. Department of Chemistry and Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, China

    Yang Teng, Chang Hai Sun, Guangzhi Li, Guangchen Sun, Jinbo Gang, Shuqing Jiao & Yu Zhang

  2. Department of Pharmacy, Kochi Medical School Hospital, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan

    Yui Nomachi, Junko Yokota, Saburo Yoshioka & Mitsuhiko Miyamura

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  1. Yang Teng
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  2. Chang Hai Sun
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  4. Guangchen Sun
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Correspondence to Mitsuhiko Miyamura.

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Teng, Y., Sun, C.H., Li, G. et al. Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine-induced in rats. J Nat Med 64, 288–294 (2010). https://doi.org/10.1007/s11418-010-0405-x

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  • DOI: https://doi.org/10.1007/s11418-010-0405-x

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