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Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata

Journal of Natural Medicines volume 64, pages 266–274 (2010)Cite this article

Abstract

In Ayurvedic medicine, Salacia reticulata is known to be useful against various metabolic diseases, including diabetes and obesity. In this study, we attempted to clarify the antiobesity mechanism and the safety of S. reticulata in vivo and in vitro. We gave ordinary MF feed, alone or mixed with S. reticulata (0.3 or 1.0%), to Tsumura Suzuki obesity diabetes (TSOD) mice (spontaneous obese type II diabetes model mice) and Tsumura Suzuki non-obese (TSNO) mice (the corresponding reference animals), ad libitum for 2 months. As compared with the TSNO control mice, the TSOD control mice became obese due to fat accumulation and developed various signs of metabolic diseases. The TSOD mouse group receiving S. reticulata showed the following effects: suppression of body weight increase and fat accumulation, alleviation of abnormal lipid metabolism and abnormal glucose tolerance, and suppression of intrahepatic fat accumulation. Also, S. reticulata prevented the mesenteric adipocyte hypertrophy recognized in TSOD mice. In the TSNO controls, the feed containing 1.0% S. reticulata exerted a suppressing effect on body weight increase and fat accumulation, but the feed containing 0.3% S. reticulata did not show any effect at all. In an in vitro experiment using mouse-derived adipocyte precursor 3T3-L1 cells, S. reticulata significantly suppressed fat accumulation in the differentiation induction phase and maturation phase. This suggested that the metabolic disease-preventing effects of S. reticulata, including the antiobesity effect, may involve suppression of differentiation and accumulation in the adipocytes.

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Acknowledgments

This work was partly supported by the “High-Tech Research Center” Project for Private University: matching fund subsidy from MEXT (Ministry of Education Culture, Sports, Science and Technology) 2004–2008 of Japan, and grant-in-aid for Scientific Research (No. 19590703) from MEXT of Japan.

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Affiliations

  1. Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo, Tokyo, 202-8585, Japan

    Tsutomu Shimada, Seiichi Iizuka & Masaki Aburada

  2. Department of Clinical Pharmacy, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan

    Eiichi Nagai, Yukiko Harasawa, Takashi Aburada & Ken-ichi Miyamoto

  3. Graduate School of Medicine, Hokkaido University, North-15, West-7, Kita-ku, Hokkaido, 060-8638, Japan

    Eiichi Nagai

  4. Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Tomoko Akase

Authors
  1. Tsutomu Shimada
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  2. Eiichi Nagai
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  3. Yukiko Harasawa
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  4. Tomoko Akase
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  5. Takashi Aburada
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  6. Seiichi Iizuka
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  7. Ken-ichi Miyamoto
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  8. Masaki Aburada
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Corresponding author

Correspondence to Masaki Aburada.

Additional information

T. Shimada and E. Nagai contributed equally to this work.

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Shimada, T., Nagai, E., Harasawa, Y. et al. Metabolic disease prevention and suppression of fat accumulation by Salacia reticulata . J Nat Med 64, 266–274 (2010). https://doi.org/10.1007/s11418-010-0401-1

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  • DOI: https://doi.org/10.1007/s11418-010-0401-1

Keywords

  • Salacia reticulata
  • TSOD
  • Adipocytes
  • Obesity