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Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii

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Phytochemical investigation of the dried leaves of Fraxinus griffithii collected in Okinawa has led to the isolation of three new secoiridoid glucosides, griffithosides A–C (13), and one new iridoid glucoside, 7-epi-7-O-(E)-caffeoylloganic acid (4), along with eight known secoiridoid glucosides (512). The structures of these compounds were elucidated by means of NMR, MS, and other spectroscopic techniques, as well as comparison with literature data. The isolated compounds were tested for radical-scavenging activity. Among them, compounds 3, 4, and 7 exhibited substantial radical-scavenging activity.

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The authors are grateful for access to the superconducting NMR instrument and the HR-ESI-MS at the Analytical Center of Molecular Medicine and the Analysis Center of Life Science, respectively, of the Graduate School of Biomedical Sciences, Hiroshima University. One (RAM) of the authors expresses his gratitude to the Ministry of Education, Sports, Culture and Technology of Japan for the academic scholarship.

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Correspondence to Hideaki Otsuka.

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Macahig, R.A., Harinantenaina, L., Matsunami, K. et al. Secoiridoid and iridoid glucosides from the leaves of Fraxinus griffithii . J Nat Med 64, 1–8 (2010).

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