Abstract
Fifteen derivatives of falconensin were examined for their inhibitory activity against the induction of ear edema in mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects. All compounds tested, except monomethylmitorubrin, inhibited the inflammatory activity induced by TPA.
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Yasukawa K, Takahashi M, Natori S, Kawai K, Yamasaki M, Takeuchi M, Takido M (1994) Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice. Oncology 51:108–112
Akihisa T, Tokuda H, Ukiya M, Kiyota A, Yasukawa K, Sakamoto N, Kimura Y, Suzuki T, Takayasu J, Nishino H (2005) Anti-tumor-promoting effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice). Chem Biodivers 2:1305–1309
Ogasawara N, Kawai K (1998) Hydrogenated azaphilones from Emericella falconensis and E. fruticulosa. Phytochemistry 47:1131–1135
Itabashi T, Nozawa K, Miyaji M, Udagawa S, Nakajima S, Kawai K (1992) Falconensins A, B, C, and D, new compounds related to azaphilon, from Emericella falconensis. Chem Pharm Bull 40:3142–3144
Itabashi T, Nozawa K, Nakajima S, Kawai K (1993) A new azaphilone, falconensin H, from Emericella falconensis. Chem Pharm Bull 41:2040–2041
Itabashi T, Ogasawara N, Nozawa K, Kawai K (1996) Isolation and structures of new azaphilone derivatives, falconensins E-G, from Emericella falconensis and absolute configurations of falconensins A–G. Chem Pharm Bull 44:2213–2217
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Yasukawa, K., Itabashi, T., Kawai, Ki. et al. Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice. J Nat Med 62, 384–386 (2008). https://doi.org/10.1007/s11418-008-0250-3
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DOI: https://doi.org/10.1007/s11418-008-0250-3