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Inhibitory effect of the rhizomes of Alpinia officinarum on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin

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Abstract

The methanol extract of galangal (the rhizomes of Alpinia officinarum L.) exhibited remarkable antitumor-promoting activity on an in vivo two-stage carcinogenesis test of mice using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Seven diarylheptanoids (1–7) were isolated and identified from the active fraction of the methanol extracts of the galangal. These compounds, 1–7, were evaluated for their inhibitory effects on TPA-induced inflammation (1 μg/ear) in mice. These compounds (1–7) tested showed marked anti-inflammatory effects, with a 50% inhibitory dose of 0.8–2.7 μmol/ear.

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Acknowledgments

This work was supported in part by A Joint Research Grant from Nihon University College of Pharmacy.

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Authors and Affiliations

  1. College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba, 274-8555, Japan

    Ken Yasukawa, Yi Sun, Susumu Kitanaka, Naoyuki Tomizawa, Motofumi Miura & Shigeyasu Motohashi

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  1. Ken Yasukawa
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  2. Yi Sun
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  3. Susumu Kitanaka
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  4. Naoyuki Tomizawa
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  5. Motofumi Miura
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  6. Shigeyasu Motohashi
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Correspondence to Ken Yasukawa.

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Yasukawa, K., Sun, Y., Kitanaka, S. et al. Inhibitory effect of the rhizomes of Alpinia officinarum on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin. J Nat Med 62, 374–378 (2008). https://doi.org/10.1007/s11418-008-0243-2

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  • DOI: https://doi.org/10.1007/s11418-008-0243-2

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